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Epigenetic Regulation of Mouse Sex Determination by the Histone Demethylase Jmjd1a
Open accessAbstract
More Determined Sex: Although several transcription factors participate in mammalian sex determination, the contribution from specific epigenetic regulation is just being revealed. Kuroki et al. (p. 1106 ) show that a JmjC domain–containing protein, Jmjd1a, catalyzes H3K9 demethylation of the Y-linked sex-determining gene Sry in mice to enable its expression above the required threshold level. Ablation of Jmjd1a function results in mouse male-to-female sex reversal, hence not only revealing a mechanism of Sry regulation but also the pivotal role of epigenetic regulation in mammalian sex determination.
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Citations
Cited by
Roles and regulation of histone methylation in animal development
Jambhekar, A., Dhall, A., & Shi, Y. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0151-1 · Cited by 556
Sex determination, gonadal sex differentiation, and plasticity in vertebrate species
Nagahama, Y., Chakraborty, T., Paul-Prasanth, B., Ohta, K., & Nakamura, M. (2021) · Physiological Reviews · doi:10.1152/physrev.00044.2019 · Cited by 346
Deveson, I. W., Holleley, C. E., Blackburn, J., Marshall Graves, J. A., Mattick, J. S., Waters, P. D., & Georges, A. (2017) · Science Advances · doi:10.1126/sciadv.1700731 · Cited by 132
“Mating of sex-reversed and wild-type homogametic individuals causes transition to TSD (9, 30), with JARID2/JMJD3 IR maintained as the regulatory signal controlling differentiation.”
BackgroundXu, S., Fan, L., Jeon, H.-Y., Zhang, F., Cui, X., Mickle, M. B., Peng, G., Hussain, A., Fazli, L., Gleave, M. E., et al. (2020) · Cancer Research · doi:10.1158/0008-5472.can-20-0233 · Cited by 64
Sex-biased chromatin and regulatory cross-talk between sex chromosomes, autosomes, and mitochondria
Silkaitis, K., & Lemos, B. (2014) · Biology of Sex Differences · doi:10.1186/2042-6410-5-2 · Cited by 39
“Males with a homozygous Kdm3a deletion exhibited frequent partial or full male-to-female sex reversal, some of which were fertile, while females lacking Kdm3a underwent normal sex differentiation and were fertile [58].”
Background
Metadata
- Authors
- Kuroki, S., Matoba, S., Akiyoshi, M., Matsumura, Y., Miyachi, H., Mise, N., Abe, K., Ogura, A., Wilhelm, D., Koopman, P., Nozaki, M., Kanai, Y., Shinkai, Y., & Tachibana, M.
- Venue
- Science
- Published
- 2013-09-06
- Volume
- 341
- Issue
- 6150
- Pages
- 1106-1109
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2075283855
- Cited by
- 258
- References
- 0
- FWCI
- 13.76
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Epigenetic Regulation of Mouse Sex Determination by the Histone Demethylase Jmjd1a. https://app.cochat.ai/papers/10.1126/science.1239864
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- Kuroki, S., Matoba, S., Akiyoshi, M., Matsumura, Y., Miyachi, H., Mise, N., Abe, K., Ogura, A., Wilhelm, D., Koopman, P., Nozaki, M., Kanai, Y., Shinkai, Y., & Tachibana, M. (2013). Epigenetic Regulation of Mouse Sex Determination by the Histone Demethylase Jmjd1a. Science. https://doi.org/10.1126/science.1239864
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