The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Functional Roles of Pulsing in Genetic Circuits
Open accessAbstract
A fundamental problem in biology is to understand how genetic circuits implement core cellular functions. Time-lapse microscopy techniques are beginning to provide a direct view of circuit dynamics in individual living cells. Unexpectedly, we are discovering that key transcription and regulatory factors pulse on and off repeatedly, and often stochastically, even when cells are maintained in constant conditions. This type of spontaneous dynamic behavior is pervasive, appearing in diverse cell types from microbes to mammalian cells. Here, we review recent work showing how pulsing is generated and controlled by underlying regulatory circuits and how it provides critical capabilities to cells in stress response, signaling, and development. A major theme is the ability of pulsing to enable time-based regulation analogous to strategies used in engineered systems. Thus, pulsatile dynamics is emerging as a central, and still largely unexplored, layer of temporal organization in the cell.
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Single-cell RNA-seq: advances and future challenges
Saliba, A.-E., Westermann, A. J., Gorski, S. A., & Vogel, J. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku555 · Cited by 847
“As reviewed elsewhere (38,129–130), a random assembly of RNA polymerase factors at the promoter influences the initial decision of whether and how efficiently a given gene will be transcribed.”
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Biased Allelic Expression in Human Primary Fibroblast Single Cells
Borel, C., Ferreira, P. G., Santoni, F., Delaneau, O., Fort, A., Popadin, K. Y., Garieri, M., Falconnet, E., Ribaux, P., Guipponi, M., et al. (2015) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2014.12.001 · Cited by 120
Delmans, M., & Hemberg, M. (2015) · doi:10.1101/020735 · Cited by 111
Metadata
- Authors
- Levine, J. H., Lin, Y., & Elowitz, M. B.
- Venue
- Science
- Published
- 2013-12-06
- Volume
- 342
- Issue
- 6163
- Pages
- 1193-1200
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1993482839
- Cited by
- 377
- References
- 46
- FWCI
- 13.04
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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