The DOI matches its Crossref record.
Mg 2+ Regulates Cytotoxic Functions of NK and CD8 T Cells in Chronic EBV Infection Through NKG2D
Open accessAbstract
Magnesium to the Rescue: Individuals with X-linked immunodeficiency with Mg 2+ defect, Epstein-Barr virus (EBV) infection, and neoplasia (XMEN) disease are genetically deficient for expression of MAGT1 , a magnesium transporter. Chaigne-Delalande et al. (p. 186 ) sought to better understand why these individuals are chronically infected with EBV at high viral loads and are susceptible to the development of lymphomas. CD8 + T cells and natural killer cells, which help to keep EBV infection in check, exhibited reduced cytotoxicity owing to their lower expression of the cell surface receptor NKG2D, which triggers cytolysis upon ligation. Magnesium supplementation in vitro and also in two XMEN patients restored levels of free Mg 2+ , increased NKG2D expression, and resulted in reduced amounts of EBV + cells, suggesting that this may be an effective therapeutic approach for XMEN patients.
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Cited by
Magnesium in man: implications for health and disease
de Baaij, J. H. F., Hoenderop, J. G. J., & Bindels, R. J. M. (2015) · Physiological Reviews · doi:10.1152/physrev.00012.2014 · Cited by 1,726
NKG2D Receptor and Its Ligands in Host Defense
Lanier, L. L. (2015) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-15-0098 · Cited by 599
“Intracellular concentrations of magnesium are critical for the assembly of the NKG2D–DAP10 receptor complex in that patients with a homozygous loss of the magnesium transporter 1 (MAGT1) gene have impaired expression of NKG2D on the surface of their T cells and NK cells, which can be restored by dietary Mgþþ supplemen…”
BackgroundTargeting Piezo1 unleashes innate immunity against cancer and infectious disease
Aykut, B., Chen, R., Kim, J. I., Wu, D., Shadaloey, S. A. A., Abengozar, R., Preiss, P., Saxena, A., Pushalkar, S., Leinwand, J., et al. (2020) · Science Immunology · doi:10.1126/sciimmunol.abb5168 · Cited by 154
The human MRS2 magnesium-binding domain is a regulatory feedback switch for channel activity
Uthayabalan, S., Vishnu, N., Madesh, M., & Stathopulos, P. B. (2023) · Life Science Alliance · doi:10.26508/lsa.202201742 · Cited by 13
Metadata
- Authors
- Chaigne-Delalande, B., Li, F.-Y., O’Connor, G. M., Lukacs, M. J., Jiang, P., Zheng, L., Shatzer, A., Biancalana, M., Pittaluga, S., Matthews, H. F., Jancel, T. J., Bleesing, J. J., Marsh, R. A., Kuijpers, T. W., Nichols, K. E., Lucas, C. L., Nagpal, S., Mehmet, H., Su, H. C., Cohen, J. I., Uzel, G., & Lenardo, M. J.
- Venue
- Science
- Published
- 2013-07-12
- Volume
- 341
- Issue
- 6142
- Pages
- 186-191
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2052090039
- Cited by
- 344
- References
- 0
- FWCI
- 13.06
- Type
- journal article
- Language
- en
- Open access
- green
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