Molecular Basis of Tubulin Transport Within the Cilium by IFT74 and IFT81
Open accessAbstract
Cilium Conundrum: The cilium has emerged as the antenna of eukaryotic cells, having numerous functions in sensory reception and developmental signaling. Several disorders, such as polycystic kidney disease, are the result of compromised cilia structure. Bhogaraju et al. (p. 1009 ) elucidate how the intraflagellar transport machinery recognizes tubulin, a ciliary cargo that is integral to cilium maintenance and formation and is constantly turned over at the cilium tip.
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The IFT-B complex proteins IFT25 and IFT27 are involved in ciliary export of hedgehog signalling components via retrograde IFT.
“whereas the IFT-B complex proteins IFT25 and IFT27 are involved in ciliary export of hedgehog (HH) signalling components via retrograde IFT 59, 60, 62, 63.”
From Cellular signalling by primary cilia in development, organ function and disease (2019) · cites this paper as [62]
Our copy’s Abstract discusses IFT74 and IFT81 binding tubulin and their role in ciliogenesis, not IFT25 or IFT27. Searches for IFT25/IFT27 and hedgehog-component export via retrograde IFT found no passage addressing the claim; page numbers are unavailable in the copy. (LLM, conf=0.76)
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References 49 · Cited by 317
- Authors
- Bhogaraju, S., Cajanek, L., Fort, C., Blisnick, T., Weber, K., Taschner, M., Mizuno, N., Lamla, S., Bastin, P., Nigg, E. A., & Lorentzen, E.
- Affiliations
- Max Planck Society (DE)
- Biozentrum, University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland.
- Centre National de la Recherche Scientifique (FR)
- Max Planck Institute of Biochemistry (DE)
- University of Basel (CH)
- Corresponding author
- Lorentzen, Esben
- ORCID
- Venue
- Science
- Published
- 2013-08-30
- Volume
- 341
- Issue
- 6149
- Pages
- 1009-1012
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC4359902
- OpenAlex
- W2026335052
- Cited by
- 317
- References
- 49
- Citations by year
- 2026: 6 · 2025: 21 · 2024: 36 · 2023: 15 · 2022: 26 · 2021: 27 · 2020: 26 · 2019: 22 · 2018: 29 · 2017: 30 · 2016: 26 · 2015: 23 · 2014: 22 · 2013: 7
- FWCI
- 17.21
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion)
- DORA PSI (Paul Scherrer Institute) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- Agence Nationale de la Recherche (ANR-11-BSV8-0016)
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (132428)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Hereditary Neurological Disorders
- Keywords
- intraflagellar transport, IFT81, cilia, ciliogenesis, calponin homology domain, basal bodies
- MeSH terms
- Cilia, Cytoskeletal Proteins, Humans, Muscle Proteins, Plant Proteins, Tubulin, Chlamydomonas reinhardtii, Point Mutation, Protein Structure, Tertiary, Crystallography, X-Ray, Protein Transport, RNA, Small Interfering, Cell Line, Tumor, Gene Knockdown Techniques
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