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Structure of the CCR5 Chemokine Receptor–HIV Entry Inhibitor Maraviroc Complex
Open accessAbstract
CCR5-Maraviroc Structure: The chemokine receptor CCR5, a G protein–coupled receptor best known as a co-receptor during HIV-1 infection, is important in a variety of physiological processes. Tan et al. (p. 1387 , published online 12 September; see the Perspective by Klasse ) now report the high-resolution crystal structure of CCR5 bound to the HIV-1 entry inhibitor, Maraviroc. The structure suggests that Maraviroc acts as a noncompetitive inhibitor by binding to a region of CCR5 that is distinct from the binding site of HIV-1 and chemokines. Comparison of the structure of CCR5 with the other HIV-1 co-receptor, the chemokine receptor CXCR4, provides insight into the co-receptor selectivity of the virus.
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Metadata
- Authors
- Tan, Q., Zhu, Y., Li, J., Chen, Z., Han, G. W., Kufareva, I., Li, T., Ma, L., Fenalti, G., Li, J., Zhang, W., Xie, X., Yang, H., Jiang, H., Cherezov, V., Liu, H., Stevens, R. C., Zhao, Q., & Wu, B.
- Venue
- Science
- Published
- 2013-09-20
- Volume
- 341
- Issue
- 6152
- Pages
- 1387-1390
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2146933058
- Cited by
- 712
- References
- 5
- FWCI
- 42.84
- Type
- journal article
- Language
- en
- Open access
- green
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- Tan, Q., Zhu, Y., Li, J., Chen, Z., Han, G. W., Kufareva, I., Li, T., Ma, L., Fenalti, G., Li, J., Zhang, W., Xie, X., Yang, H., Jiang, H., Cherezov, V., Liu, H., Stevens, R. C., Zhao, Q., & Wu, B. (2013). Structure of the CCR5 Chemokine Receptor–HIV Entry Inhibitor Maraviroc Complex. Science. https://doi.org/10.1126/science.1241475
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