The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Erythropoietin Derived by Chemical Synthesis
Open accessAbstract
EPO via Total Synthesis: Erythropoietin (EPO) is a hormone involved in the production of red blood cells. Synthetic EPO produced via genetically engineered cell cultures is used to treat anemia and—more controversially—to boost athletic performance. EPO is a glycoprotein, and though its protein component is well-defined, both natural and synthetic EPO exhibit a wide range of attached oligosaccharides. Wang et al. (p. 1357 ; see the Perspective by Hsieh-Wilson and Griffin ) prepared an EPO sample by a chemical synthesis that maintains a uniform pattern of attached sugars throughout, which may prove helpful in the analysis of how variation in the sugar components of EPO impact function.
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Cites
Structural analysis of the glycosylation of gene-activated erythropoietin (epoetin delta, Dynepo)
Llop, E., Gutiérrez-Gallego, R., Segura, J., Mallorquí, J., & Pascual, J. A. (2008) · Analytical Biochemistry · doi:10.1016/j.ab.2008.08.027 · Cited by 79
Cited by
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Rosen, C. B., & Francis, M. B. (2017) · Nature Chemical Biology · doi:10.1038/nchembio.2416 · Cited by 389
Expanding the chemical toolbox for the synthesis of large and uniquely modified proteins
Bondalapati, S., Jbara, M., & Brik, A. (2016) · Nature Chemistry · doi:10.1038/nchem.2476 · Cited by 359
Chemical and Biochemical Perspectives of Protein Lysine Methylation
Luo, M. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00008 · Cited by 284
Seino, J., Fujihira, H., Nakakita, S.-I., Masahara-Negishi, Y., Miyoshi, E., Hirabayashi, J., & Suzuki, T. (2016) · Glycobiology · doi:10.1093/glycob/cww048 · Cited by 23
Metadata
- Authors
- Wang, P., Dong, S., Shieh, J.-H., Peguero, E., Hendrickson, R., Moore, M. A. S., & Danishefsky, S. J.
- Venue
- Science
- Published
- 2013-12-13
- Volume
- 342
- Issue
- 6164
- Pages
- 1357-1360
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2045301848
- Cited by
- 269
- References
- 1
- FWCI
- 14.01
- Type
- journal article
- Language
- en
- Open access
- green
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