The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Reversal of Female Infertility by Chk2 Ablation Reveals the Oocyte DNA Damage Checkpoint Pathway
Open accessAbstract
Eggs Well Done: Germ cells can endure extensive DNA damage during their development. Programmed meiotic double-strand breaks (DSBs) are essential for proper segregation of chromosomes to oocytes and sperm. However, incomplete DSB repair by recombination activates a checkpoint that triggers cell death. Exogenous DNA damage is also lethal to oocytes via a highly sensitive checkpoint. Bolcun-Filas et al. (p. 533 ) show that the CHK2 kinase is a key component of both checkpoints in mouse oocytes. Deletion of Chk2 restored fertility to females that would otherwise be sterile because of a meiotic recombination mutation or radiation exposure.
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Atm-Deficient Mice: A Paradigm of Ataxia Telangiectasia
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Self-citationp63 protects the female germ line during meiotic arrest
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Cited by
CHK2 kinase in the DNA damage response and beyond
Zannini, L., Delia, D., & Buscemi, G. (2014) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mju045 · Cited by 455
Structural Evolution and Dynamics of the p53 Proteins
Chillemi, G., Kehrloesser, S., Bernassola, F., Desideri, A., Dötsch, V., Levine, A. J., & Melino, G. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a028308 · Cited by 65
Mills, M., Emori, C., Kumar, P., Boucher, Z., George, J., & Bolcun-Filas, E. (2025) · Developmental Biology · doi:10.1016/j.ydbio.2024.09.007 · Cited by 12
Self-citationRare SNP in the HELB gene interferes with RPA interaction and cellular function of HELB
(2025) · doi:10.1093/narmme/ugaf019
Metadata
- Authors
- Bolcun-Filas, E., Rinaldi, V. D., White, M. E., & Schimenti, J. C.
- Venue
- Science
- Published
- 2014-01-31
- Volume
- 343
- Issue
- 6170
- Pages
- 533-536
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1999301366
- Cited by
- 277
- References
- 29
- FWCI
- 6.94
- Type
- journal article
- Language
- en
- Open access
- green
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- Bolcun-Filas, E., Rinaldi, V. D., White, M. E., & Schimenti, J. C. (2014). Reversal of Female Infertility by Chk2 Ablation Reveals the Oocyte DNA Damage Checkpoint Pathway. Science. https://doi.org/10.1126/science.1247671
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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