The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Flavivirus NS1 Structures Reveal Surfaces for Associations with Membranes and the Immune System
Open accessAbstract
Two-Faced Viral Protein: Flaviviruses cause human diseases such as West Nile fever and dengue fever. The flavivirus nonstructural protein 1 (NS1) has multiple functions in flavivirus biology and is a target for vaccine development. Dimeric NS1 is essential for replication of the viral genome inside host cells, while hexameric NS1 is secreted and plays a role in evasion of the immune system. Akey et al. (p. 881 , published online 6 February; see the Perspective by Shi ) report crystal structures for full-length glycosylated NS1 from West Nile and dengue viruses. The structures show a hexamer comprised of three dimers. The structural analysis together with liposome and mutational studies identify a membrane interacting surface on one face of the dimer and an immune evasion surface on the other.
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Cited by
Modhiran, N., Watterson, D., Muller, D. A., Panetta, A. K., Sester, D. P., Liu, L., Hume, D. A., Stacey, K. J., & Young, P. R. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa3863 · Cited by 549
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Sex differences in inflammation, redox biology, mitochondria and autoimmunity
Di Florio, D. N., Sin, J., Coronado, M. J., Atwal, P. S., & Fairweather, D. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101482 · Cited by 185
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(2022) · doi:10.1101/2022.04.06.487425 · Cited by 4
Metadata
- Authors
- Akey, D. L., Brown, W. C., Dutta, S., Konwerski, J., Jose, J., Jurkiw, T. J., DelProposto, J., Ogata, C. M., Skiniotis, G., Kuhn, R. J., & Smith, J. L.
- Venue
- Science
- Published
- 2014-02-21
- Volume
- 343
- Issue
- 6173
- Pages
- 881-885
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2119525935
- Cited by
- 434
- References
- 39
- FWCI
- 32.17
- Type
- journal article
- Language
- en
- Open access
- green
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- Akey, D. L., Brown, W. C., Dutta, S., Konwerski, J., Jose, J., Jurkiw, T. J., DelProposto, J., Ogata, C. M., Skiniotis, G., Kuhn, R. J., & Smith, J. L. (2014). Flavivirus NS1 Structures Reveal Surfaces for Associations with Membranes and the Immune System. Science. https://doi.org/10.1126/science.1247749
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