The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Detection of a Recurrent DNAJB1-PRKACA Chimeric Transcript in Fibrolamellar Hepatocellular Carcinoma
Open accessAbstract
Oncogenic Suspect Exposed: It can be difficult logistically to study the genomics of rare variants of common cancers. Nevertheless, Honeyman et al. (p. 1010 ) studied fibrolamellar hepatocellular carcinoma (FL-HCC), a rare and poorly understood liver tumor that affects adolescents and young adults and for which there is no effective treatment. FL-HCCs from 15 patients all expressed a chimeric RNA transcript and protein containing sequences from a molecular chaperone fused in frame with sequences from the catalytic domain of protein kinase A. The chimeric protein retained kinase activity in vitro. Such recurrent gene fusions in cancer may signal a role in pathogenesis and provide an opportunity for therapeutic intervention.
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Metadata
- Authors
- Honeyman, J. N., Simon, E. P., Robine, N., Chiaroni-Clarke, R., Darcy, D. G., Lim, I. I. P., Gleason, C. E., Murphy, J. M., Rosenberg, B. R., Teegan, L., Takacs, C. N., Botero, S., Belote, R., Germer, S., Emde, A.-K., Vacic, V., Bhanot, U., LaQuaglia, M. P., & Simon, S. M.
- Venue
- Science
- Published
- 2014-02-28
- Volume
- 343
- Issue
- 6174
- Pages
- 1010-1014
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1974489853
- Cited by
- 494
- References
- 30
- FWCI
- 21.11
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Honeyman, J. N., Simon, E. P., Robine, N., Chiaroni-Clarke, R., Darcy, D. G., Lim, I. I. P., Gleason, C. E., Murphy, J. M., Rosenberg, B. R., Teegan, L., Takacs, C. N., Botero, S., Belote, R., Germer, S., Emde, A.-K., Vacic, V., Bhanot, U., LaQuaglia, M. P., & Simon, S. M. (2014). Detection of a Recurrent DNAJB1-PRKACA Chimeric Transcript in Fibrolamellar Hepatocellular Carcinoma. Science. https://doi.org/10.1126/science.1249484
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
