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Cited by 285

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Reductive Cleavage of Disulfide Bridges in Ribonuclease

Sela, Michael, White, Frederick H., Anfinsen, Christian B.·1957·Science

Abstract

This article was the first of many studies that were generally concerned with the eventual total synthesis of the protein. It contained several original observations that would lead to the conclusion that the refolding of the ribonuclease molecule after full denaturation by reductive cleavage of its four disulfide bonds required that only one of the one hundred five possible pairings of eight sulfhydryl groups to form four disulfide linkages take place.

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Metadata

Authors
Sela, M., White, F. H., & Anfinsen, C. B.
Venue
Science
Published
1957-04-12
Volume
125
Issue
3250
Pages
691-692
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2070569568
Cited by
285
References
0
FWCI
9.45
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Reductive Cleavage of Disulfide Bridges in Ribonuclease. https://app.cochat.ai/papers/10.1126/science.125.3250.691
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Sela, M., White, F. H., & Anfinsen, C. B. (1957). Reductive Cleavage of Disulfide Bridges in Ribonuclease. Science. https://doi.org/10.1126/science.125.3250.691

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.