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Reductive Cleavage of Disulfide Bridges in Ribonuclease
Abstract
This article was the first of many studies that were generally concerned with the eventual total synthesis of the protein. It contained several original observations that would lead to the conclusion that the refolding of the ribonuclease molecule after full denaturation by reductive cleavage of its four disulfide bonds required that only one of the one hundred five possible pairings of eight sulfhydryl groups to form four disulfide linkages take place.
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Citations
Cited by
Principles that Govern the Folding of Protein Chains
Anfinsen, C. B. (1973) · Science · doi:10.1126/science.181.4096.223 · Cited by 7,096
Self-citationIntrinsically disordered protein
Dunker, A. K., Lawson, J. D., Brown, C. J., Williams, R. M., Romero, P., Oh, J. S., Oldfield, C. J., Campen, A. M., Ratliff, C. M., Hipps, K. W., et al. (2001) · Journal of Molecular Graphics and Modelling · doi:10.1016/s1093-3263(00)00138-8 · Cited by 2,272
Intrinsically Disordered Proteins
Uversky, V. N. (2013) · Brenner's Encyclopedia of Genetics · doi:10.1016/b978-0-12-374984-0.01698-3 · Cited by 1,637
Raines, R. T. (1998) · Chemical Reviews · doi:10.1021/cr960427h · Cited by 937
Xie, H., Vucetic, S., Iakoucheva, L. M., Oldfield, C. J., Dunker, A. K., Uversky, V. N., & Obradovic, Z. (2007) · Journal of Proteome Research · doi:10.1021/pr060392u · Cited by 560
Metadata
- Authors
- Sela, M., White, F. H., & Anfinsen, C. B.
- Venue
- Science
- Published
- 1957-04-12
- Volume
- 125
- Issue
- 3250
- Pages
- 691-692
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2070569568
- Cited by
- 285
- References
- 0
- FWCI
- 9.45
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sela, M., White, F. H., & Anfinsen, C. B. (1957). Reductive Cleavage of Disulfide Bridges in Ribonuclease. Science. https://doi.org/10.1126/science.125.3250.691
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.