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Antagonism of Stimulation-Produced Analgesia by Naloxone, a Narcotic Antagonist
Abstract
Analgesia produced by focal electrical stimulation of the brain is partially reversed by the narcotic antagonist naloxone. The absence of complete reversal does not appear to be caused by inadequate doses of naloxone since doses higher than 1 milligram per kilogram of body weight did not increase the antagonism. It is suggested that stimulation-produced analgesia may result, at least in part, from release of an endogenous, narcotic-like substance, such as that recently reported by other investigators.
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Citations
Cited by
Millan, M. J. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00009-6 · Cited by 3,035
Organization of endogenous opiate and nonopiate pain control systems
Watkins, L. R., & Mayer, D. J. (1982) · Science · doi:10.1126/science.6281891 · Cited by 791
Self-citationAntagonism of acupuncture analgesia in man by the narcotic antagonist naloxone
Mayer, D. J., Price, D. D., & Rafii, A. (1977) · Brain Research · doi:10.1016/0006-8993(77)90161-5 · Cited by 759
Self-citationValet, M., Sprenger, T., Boecker, H., Willoch, F., Rummeny, E., Conrad, B., Erhard, P., & Tolle, T. R. (2004) · Pain · doi:10.1016/j.pain.2004.02.033 · Cited by 708
Imaging attentional modulation of pain in the periaqueductal gray in humans
Tracey, I., Ploghaus, A., Gati, J. S., Clare, S., Smith, S., Menon, R. S., & Matthews, P. M. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-07-02748.2002 · Cited by 569
Metadata
- Authors
- Akil, H., Mayer, D. J., & Liebeskind, J. C.
- Venue
- Science
- Published
- 1976-03-05
- Volume
- 191
- Issue
- 4230
- Pages
- 961-962
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2025414544
- Cited by
- 669
- References
- 0
- FWCI
- 62.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- Akil, H., Mayer, D. J., & Liebeskind, J. C. (1976). Antagonism of Stimulation-Produced Analgesia by Naloxone, a Narcotic Antagonist. Science. https://doi.org/10.1126/science.1251210
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
