Coordination of progenitor specification and growth in mouse and chick spinal cord
Open accessAbstract
Development requires tissue growth as well as cell diversification. To address how these processes are coordinated, we analyzed the development of molecularly distinct domains of neural progenitors in the mouse and chick neural tube. We show that during development, these domains undergo changes in size that do not scale with changes in overall tissue size. Our data show that domain proportions are first established by opposing morphogen gradients and subsequently controlled by domain-specific regulation of differentiation rate but not differences in proliferation rate. Regulation of differentiation rate is key to maintaining domain proportions while accommodating both intra- and interspecies variations in size. Thus, the sequential control of progenitor specification and differentiation elaborates pattern without requiring that signaling gradients grow as tissues expand.
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Progenitor domain sizes in the spinal cord change over time.
“Previous work has indicated that progenitor domain sizes in the spinal cord change over time (Kicheva and Briscoe, 2015; Kicheva et al., 2014).”
From Single cell transcriptomics reveals spatial and temporal dynamics of gene expression in the developing mouse spinal cord (2019) · cites this paper as Kicheva et al., 2014
The prominence of motor neurons at early stages is consistent with the initially high differentiation rate of MN progenitors.
“which is consistent with the initially high differentiation rate of MN progenitors”
From Single cell transcriptomics reveals spatial and temporal dynamics of gene expression in the developing mouse spinal cord (2019) · cites this paper as Kicheva et al., 2014
The proportion of neurons increases in the spinal cord over time.
“which is consistent with the proportion of neurons increasing in the spinal cord over time (Kicheva et al., 2014)”
From Single cell transcriptomics reveals spatial and temporal dynamics of gene expression in the developing mouse spinal cord (2019) · cites this paper as Kicheva et al., 2014
The proportions of cells recovered from the assignment of cell identities closely match the growth dynamics of the spinal cord quantified in Kicheva et al. (2014).
“This revealed a close match (Fig. 2E), which allowed us to extend the analysis.”
From Single cell transcriptomics reveals spatial and temporal dynamics of gene expression in the developing mouse spinal cord (2019) · cites this paper as Kicheva et al., 2014
The proportions of cell types recovered matched previously determined proportions in the spinal cord.
“Reassuringly, the proportions of the cell types recovered matched previously determined proportions in the spinal cord (Kicheva et al., 2014), which suggests that the methods did not substantially bias the composition of the transcriptomes recovered.”
From Single cell transcriptomics reveals spatial and temporal dynamics of gene expression in the developing mouse spinal cord (2019) · cites this paper as Kicheva et al., 2014
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References 56 · Cited by 180
- Authors
- Kicheva, A., Bollenbach, T., Ribeiro, A., Valle, H. P., Lovell-Badge, R., Episkopou, V., & Briscoe, J.
- Affiliations
- National Institute for Medical Research (GB)
- Institute of Science and Technology Austria (AT)
- Imperial College London (GB)
- Corresponding author
- Briscoe, James
- ORCID
- Venue
- Science
- Published
- 2014-09-26
- Volume
- 345
- Issue
- 6204
- Pages
- 1254927-1254927
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC4228193
- OpenAlex
- W2058903813
- Cited by
- 180
- References
- 56
- Citations by year
- 2026: 10 · 2025: 22 · 2024: 23 · 2023: 14 · 2022: 11 · 2021: 14 · 2020: 16 · 2019: 19 · 2018: 12 · 2017: 13 · 2016: 13 · 2015: 12 · 2014: 1
- FWCI
- 4.52
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Wellcome Trust (098326, 98326, WT098326MA)
- Medical Research Council (MR/J013331/1)
- Biotechnology and Biological Sciences Research Council (BB/G00577X/1, BB/G00577X/2)
- National Institute of Biomedical Imaging and Bioengineering (R01EB016629)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- spinal cord development, neural tube, morphogen gradients, cell proliferation, tissue growth, mice, chick embryo, interspecies variation
- MeSH terms
- Animals, Cell Differentiation, Chick Embryo, Models, Biological, Spinal Cord, Stem Cells, Body Patterning, Mice, Neural Tube
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