Cited by 179Biomedical Ethics and RegulationViral Infectious Diseases and Gene Expression in InsectsResearch Data Management Practices

Fixing problems with cell lines

Open access
Lorsch, Jon R., Collins, Francis S., Lippincott-Schwartz, Jennifer·2014·Science

Abstract

Technologies and policies can improve authentication

Integrity signals

Registry

Crossref · 10.1126/science.1259110

Cites

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  • Current calls for action and remediation activities are almost exclusively concerned with avoiding future contaminations, such as through systems for easier verification of cell line identities.

    “The current calls for action and remediation activities are almost exclusively concerned with avoiding future contaminations, such as through systems for easier verification of cell line identities. Various solutions have been proposed [27–29], among others employing genotypic identification through short tandem repeats (STR) [30].”

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References 12 · Cited by 179

Authors
Lorsch, J. R., Collins, F. S., & Lippincott-Schwartz, J.
Affiliations
  • National Institute of General Medical Sciences (US)
  • National Institutes of Health (US)
  • President, American Society for Cell Biology, Bethesda, MD 20814, USA.
Corresponding author
Lorsch, Jon R.
Venue
Science
Published
2014-12-19
Volume
346
Issue
6216
Pages
1452-1453
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W1975611355
Cited by
179
References
12
Citations by year
2026: 6 · 2025: 8 · 2024: 6 · 2023: 6 · 2022: 13 · 2021: 27 · 2020: 22 · 2019: 23 · 2018: 20 · 2017: 20 · 2016: 11 · 2015: 17
FWCI
10.64
Type
journal article
Language
en
Open access
Locations
  • Science (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Biomedical Ethics and Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Viral Infectious Diseases and Gene Expression in Insects
  • Physical Sciences › Computer Science › Information Systems › Research Data Management Practices
Keywords
cell line authentication, cell line misidentification, research integrity, biobanking, authentication technology, authentication policies
MeSH terms
Animals, Cell Line, Drug Evaluation, Preclinical, Humans, National Institutes of Health (U.S.), United States, Reproducibility of Results, Biological Specimen Banks, Biomedical Research, Policy

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