Fixing problems with cell lines
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Technologies and policies can improve authentication
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Current calls for action and remediation activities are almost exclusively concerned with avoiding future contaminations, such as through systems for easier verification of cell line identities.
“The current calls for action and remediation activities are almost exclusively concerned with avoiding future contaminations, such as through systems for easier verification of cell line identities. Various solutions have been proposed [27–29], among others employing genotypic identification through short tandem repeats (STR) [30].”
From The ghosts of HeLa: How cell line misidentification contaminates the scientific literature (2017) · cites this paper as [28]
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References 12 · Cited by 179
- Authors
- Lorsch, J. R., Collins, F. S., & Lippincott-Schwartz, J.
- Affiliations
- National Institute of General Medical Sciences (US)
- National Institutes of Health (US)
- President, American Society for Cell Biology, Bethesda, MD 20814, USA.
- Corresponding author
- Lorsch, Jon R.
- Venue
- Science
- Published
- 2014-12-19
- Volume
- 346
- Issue
- 6216
- Pages
- 1452-1453
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC5101941
- OpenAlex
- W1975611355
- Cited by
- 179
- References
- 12
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 6 · 2023: 6 · 2022: 13 · 2021: 27 · 2020: 22 · 2019: 23 · 2018: 20 · 2017: 20 · 2016: 11 · 2015: 17
- FWCI
- 10.64
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Biomedical Ethics and Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Viral Infectious Diseases and Gene Expression in Insects
- Physical Sciences › Computer Science › Information Systems › Research Data Management Practices
- Keywords
- cell line authentication, cell line misidentification, research integrity, biobanking, authentication technology, authentication policies
- MeSH terms
- Animals, Cell Line, Drug Evaluation, Preclinical, Humans, National Institutes of Health (U.S.), United States, Reproducibility of Results, Biological Specimen Banks, Biomedical Research, Policy
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