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Analgesia Mediated by a Direct Spinal Action of Narcotics
Abstract
Narcotic analgetics administered directly into the spinal subarachnoid space of the rat via a chronically inserted catheter produce a potent analgesia that can be antagonized by naloxone. The narcotics, acting only at the spinal level, changed cord function to block not only spinal reflexes but also the operant response to painful stimuli.
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Citations
Cited by
Schäfers, M., Svensson, C. I., Sommer, C., & Sorkin, L. S. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-07-02517.2003 · Cited by 519
The role of dopamine in the nucleus accumbens in analgesia
Altier, N., & Stewart, J. (1999) · Life Sciences · doi:10.1016/s0024-3205(99)00298-2 · Cited by 273
EZH2 regulates spinal neuroinflammation in rats with neuropathic pain
Yadav, R., & Weng, H.-R. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.02.041 · Cited by 78
Sucrose ingestion causes opioid analgesia.
Segato, F. N., Castro-Souza, C., Segato, E. N., Morato, S., & Coimbra, N. C. (1997) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x1997000800011 · Cited by 72
Walia, V., Chaudhary, S. K., & Kumar Sethiya, N. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2020.104939 · Cited by 51
Metadata
- Authors
- Yaksh, T. L., & Rudy, T. A.
- Venue
- Science
- Published
- 1976-06-25
- Volume
- 192
- Issue
- 4246
- Pages
- 1357-1358
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1989423171
- Cited by
- 940
- References
- 0
- FWCI
- 27.77
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yaksh, T. L., & Rudy, T. A. (1976). Analgesia Mediated by a Direct Spinal Action of Narcotics. Science. https://doi.org/10.1126/science.1273597
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
