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Immunoglobulin A-Induced Shift of Epstein-Barr Virus Tissue Tropism
Abstract
Increased immunoglobulin A (IgA) antibodies to the Epstein-Barr virus (EBV) appear months to years before the clinical onset of nasopharyngeal carcinoma and define populations at high risk for this EBV-associated epithelial cancer common in south China. In the human HT-29 epithelial cell line, polymeric IgA (pIgA) specific for EBV promoted infection of the otherwise refractory epithelial cells. When bound to pIgA, EBV entered epithelial cells through secretory component-mediated IgA transport but no longer infected B lymphocytes. Such an immune-induced shift in EBV tissue tropism provides a paradigm for endogenous spread of EBV in the immune host that predicts infectious sequelae of epithelium.
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Cited by
INTERACTION OF ANTIGENS AND ANTIBODIES AT MUCOSAL SURFACES
Lamm, M. E. (1997) · Annual Review of Microbiology · doi:10.1146/annurev.micro.51.1.311 · Cited by 429
Antibody‐dependent enhancement of viral infection: molecular mechanisms and in vivo implications
Takada, A., & Kawaoka, Y. (2003) · Reviews in Medical Virology · doi:10.1002/rmv.405 · Cited by 332
Epstein-Barr virus reactivation and upper-respiratory illness in elite swimmers
GLEESON, M., PYNE, D. B., P. AUSTIN, J., LYNN FRANCIS, J., CLANCY, R. L., MCDONALD, W. A., & FRICKER, P. A. (2002) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200203000-00005 · Cited by 129
Metadata
- Authors
- Sixbey, J. W., & Yao, Q.-Y.
- Venue
- Science
- Published
- 1992-03-20
- Volume
- 255
- Issue
- 5051
- Pages
- 1578-1580
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1972140850
- Cited by
- 221
- References
- 0
- FWCI
- 5.46
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Immunoglobulin A-Induced Shift of Epstein-Barr Virus Tissue Tropism. https://app.cochat.ai/papers/10.1126/science.1312750
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- Sixbey, J. W., & Yao, Q.-Y. (1992). Immunoglobulin A-Induced Shift of Epstein-Barr Virus Tissue Tropism. Science. https://doi.org/10.1126/science.1312750
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
