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A Molecular Theory of General Anesthesia: Anesthesia is attributed to the formation in the brain of minute hydrate crystals of the clathrate type.
Abstract
During the last twenty years much \nprogress has been made in the determination \nof the molecular structure of \nliving organisms and the understanding \nof biological phenomena in terms of \nthe structure of molecules and their \ninteraction with one another. The progress \nthat has been made. in the field of \nmolecular biology during this period \nhas related in the main to somatic and \ngenetic aspects of physiology, rather \nthan to psychic. We may now have \nreached the time when a successful \nmolecular attack on psychobiology, including \nthe nature of encephalonic \nmechanisms, consciousness, memory, \nnarcosis, sedation, and similar phenomena, \ncan be initiated. As one of the \nsteps in this attack I have formulated \na rather detailed theory of general \nanesthesia, which is described in the \nfollowing paragraphs (1).
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Citations
Cited by
Molecular mechanisms of general anaesthesia
Franks, N. P., & Lieb, W. R. (1982) · Nature · doi:10.1038/300487a0 · Cited by 434
Diffusion Magnetic Resonance Imaging: What Water Tells Us about Biological Tissues
Le Bihan, D., & Iima, M. (2015) · PLOS Biology · doi:10.1371/journal.pbio.1002203 · Cited by 297
The Quest for a Unified Model of Anesthetic Action: A Century in Claude Bernard's Shadow
Perouansky, M. (2012) · Anesthesiology · doi:10.1097/aln.0b013e318264492e · Cited by 52
Metadata
- Authors
- Pauling, L.
- Venue
- Science
- Published
- 1961-07-07
- Volume
- 134
- Issue
- 3471
- Pages
- 15-21
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2001391235
- Cited by
- 432
- References
- 0
- FWCI
- 52.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: A Molecular Theory of General Anesthesia: Anesthesia is attributed to the formation in the brain of minute hydrate crystals of the clathrate type. https://app.cochat.ai/papers/10.1126/science.134.3471.15
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- Pauling, L. (1961). A Molecular Theory of General Anesthesia: Anesthesia is attributed to the formation in the brain of minute hydrate crystals of the clathrate type. Science. https://doi.org/10.1126/science.134.3471.15
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
