Strain and Sex Differences in Serum Cholesterol Levels of Mice
Abstract
Five inbred strains of mice differed significantly in serum cholesterol level. Cholesterol levels ranged from 128 mg/100 ml in C57B1/6 mice to 208 mg/100 ml in C3H mice. Cholesterol level was significantly higher in males than in females. The cholesterol level of 2-month-old mice did not differ from that of 1-year-old mice.
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Male mice had higher plasma CHOL, TRIG, and VLDL than females.
“Male mice had higher plasma CHOL (Fig. 1b), TRIG (Supp. Figure 2a), and VLDL (Supp. Figure 2b) than females, as previously reported [42].”
From APOE Christchurch enhances a disease-associated microglial response to plaque but suppresses response to tau pathology (2025) · cites this paper as [42]
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Tran, K. M., Kwang, N. E., Butler, C. A., Gomez-Arboledas, A., Kawauchi, S., Mar, C., Chao, D., Barahona, R. A., Da Cunha, C., Tsourmas, K. I., et al. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-024-00793-x · Cited by 28 · see citing works
- Authors
- Bruell, J. H., Daroczy, A. F., & Hellerstein, H. K.
- Affiliations
- Case Western Reserve University (US)
- School of Medicine, Western Reserve University
- Venue
- Science
- Published
- 1962-03-23
- Volume
- 135
- Issue
- 3508
- Pages
- 1071-1072
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2058640589
- Cited by
- 52
- References
- 0
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 3 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 3 · 2015: 2 · 2014: 3
- FWCI
- 8.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- serum cholesterol, inbred mouse strains, sex differences, age differences, C57BL/6 mice, C3H mice
- MeSH terms
- Animals, Cholesterol, Female, Genetics, Male, Mice, Inbred C3H, Sex Characteristics, Mice
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