The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Primary structure and functional expression of the beta 1 subunit of the rat brain sodium channel
Abstract
Voltage-sensitive sodium channels are responsible for the initiation and propagation of the action potential and therefore are important for neuronal excitability. Complementary DNA clones encoding the beta 1 subunit of the rat brain sodium channel were isolated by a combination of polymerase chain reaction and library screening techniques. The deduced primary structure indicates that the beta 1 subunit is a 22,851-dalton protein that contains a single putative transmembrane domain and four potential extracellular N-linked glycosylation sites, consistent with biochemical data. Northern blot analysis reveals a 1,400-nucleotide messenger RNA in rat brain, heart, skeletal muscle, and spinal cord. Coexpression of beta 1 subunits with alpha subunits increases the size of the peak sodium current, accelerates its inactivation, and shifts the voltage dependence of inactivation to more negative membrane potentials. These results indicate that the beta 1 subunit is crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the rat brain sodium channel.
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Cites
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
Kozak, M. (1986) · Cell · doi:10.1016/0092-8674(86)90762-2 · Cited by 4,741
Cited by
From Ionic Currents to Molecular Mechanisms
Catterall, W. A. (2000) · Neuron · doi:10.1016/s0896-6273(00)81133-2 · Cited by 2,118
Self-citationWallace, R. H., Wang, D. W., Singh, R., Scheffer, I. E., George, A. L., Phillips, H. A., Saar, K., Reis, A., Johnson, E. W., Sutherland, G. R., et al. (1998) · Nature Genetics · doi:10.1038/1252 · Cited by 996
Inactivation properties of voltage-gated K+ channels altered by presence of β-subunit
Rettig, J., Heinemann, S. H., Wunder, F., Lorra, C., Parcej, D. N., Oliver Dolly, J., & Pongs, O. (1994) · Nature · doi:10.1038/369289a0 · Cited by 852
The Role of Voltage-Gated Sodium Channels in Pain Signaling
Bennett, D. L., Clark, A. J., Huang, J., Waxman, S. G., & Dib-Hajj, S. D. (2019) · Physiological Reviews · doi:10.1152/physrev.00052.2017 · Cited by 730
Resurgence of sodium channel research
Goldin, A. L. (2001) · Annual Review of Physiology · doi:10.1146/annurev.physiol.63.1.871 · Cited by 688
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Metadata
- Authors
- Isom, L., De Jongh, K., Patton, D., Reber, B., Offord, J., Charbonneau, H., Walsh, K., Goldin, A., & Catterall, W.
- Venue
- Science
- Published
- 1992-05-08
- Volume
- 256
- Issue
- 5058
- Pages
- 839-842
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1985146688
- Cited by
- 711
- References
- 2
- FWCI
- 13.23
- Type
- journal article
- Language
- en
- Open access
- closed
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- Isom, L., De Jongh, K., Patton, D., Reber, B., Offord, J., Charbonneau, H., Walsh, K., Goldin, A., & Catterall, W. (1992). Primary structure and functional expression of the beta 1 subunit of the rat brain sodium channel. Science. https://doi.org/10.1126/science.1375395
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