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Identification of a Protein that Binds to the SH3 Region of Abl and Is Similar to Bcr and GAP-rho
Abstract
A Src homology 3 (SH3) region is a sequence of approximately 50 amino acids found in many nonreceptor tyrosine kinases and other proteins. Deletion of the SH3 region from the protein encoded by the c- abl proto-oncogene activates the protein's transforming capacity, thereby suggesting the participation of the SH3 region in the negative regulation of transformation. A complementary DNA was isolated that encoded a protein, 3BP-1, to which the SH3 region of Abl bound with high specificity and to which SH3 regions from other proteins bound differentially. The sequence of the 3BP-1 protein is similar to that of a COOH-terminal segment of Bcr and to guanosine triphosphatase-activating protein (GAP)-rho, which suggests that it might have GAP activity for Ras-related proteins. The 3BP-1 protein may therefore be a mediator of SH3 function in transformation inhibition and may link tyrosine kinases to Ras-related proteins.
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Cited by
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Hirano, T. (1998) · International Reviews of Immunology · doi:10.3109/08830189809042997 · Cited by 788
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Mayer, B. J. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.7.1253 · Cited by 788
Self-citationFeng, S., Chen, J. K., Yu, H., Simon, J. A., & Schreiber, S. L. (1994) · Science · doi:10.1126/science.7526465 · Cited by 687
Pendergast, A. M., Quilliam, L. A., Cripe, L. D., Bassing, C. H., Dai, Z., Li, N., Batzer, A., Rabun, K. M., Der, C. J., Schlessinger, J., et al. (1993) · Cell · doi:10.1016/0092-8674(93)90689-n · Cited by 659
Metadata
- Authors
- Cicchetti, P., Mayer, B. J., Thiel, G., & Baltimore, D.
- Venue
- Science
- Published
- 1992-08-07
- Volume
- 257
- Issue
- 5071
- Pages
- 803-806
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1971377120
- Cited by
- 546
- References
- 0
- FWCI
- 37.92
- Type
- journal article
- Language
- en
- Open access
- closed
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- Cicchetti, P., Mayer, B. J., Thiel, G., & Baltimore, D. (1992). Identification of a Protein that Binds to the SH3 Region of Abl and Is Similar to Bcr and GAP-rho. Science. https://doi.org/10.1126/science.1379745
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