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Estimating Genomic Distance from DNA Sequence Location in Cell Nuclei by a Random Walk Model
Abstract
The folding of chromatin in interphase cell nuclei was studied by fluorescent in situ hybridization with pairs of unique DNA sequence probes. The sites of DNA sequences separated by 100 to 2000 kilobase pairs (kbp) are distributed in interphase chromatin according to a random walk model. This model provides the basis for calculating the spacing of sequences along the linear DNA molecule from interphase distance measurements. An interphase mapping strategy based on this model was tested with 13 probes from a 4-megabase pair (Mbp) region of chromosome 4 containing the Huntington disease locus. The results confirmed the locations of the probes and showed that the remaining gap in the published maps of this region is negligible in size. Interphase distance measurements should facilitate construction of chromosome maps with an average marker density of one per 100 kbp, approximately ten times greater than that achieved by hybridization to metaphase chromosomes.
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Cited by
Exploring the three-dimensional organization of genomes: Interpreting chromatin interaction data
Dekker, J., Marti-Renom, M. A., & Mirny, L. A. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3454 · Cited by 1,068
Robinett, C. C., Straight, A., Li, G., Willhelm, C., Sudlow, G., Murray, A., & Belmont, A. S. (1996) · The Journal of cell biology · doi:10.1083/jcb.135.6.1685 · Cited by 720
Chambeyron, S., & Bickmore, W. A. (2004) · Genes & Development · doi:10.1101/gad.292104 · Cited by 623
Proximity of Chromosomal Loci That Participate in Radiation-Induced Rearrangements in Human Cells
Nikiforova, M. N., Stringer, J. R., Blough, R., Medvedovic, M., Fagin, J. A., & Nikiforov, Y. E. (2000) · Science · doi:10.1126/science.290.5489.138 · Cited by 468
The new cytogenetics: blurring the boundaries with molecular biology
Speicher, M. R., & Carter, N. P. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1692 · Cited by 458
Metadata
- Authors
- van den Engh, G., Sachs, R., & Trask, B. J.
- Venue
- Science
- Published
- 1992-09-04
- Volume
- 257
- Issue
- 5075
- Pages
- 1410-1412
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2027867510
- Cited by
- 240
- References
- 0
- FWCI
- 4.84
- Type
- journal article
- Language
- en
- Open access
- closed
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- van den Engh, G., Sachs, R., & Trask, B. J. (1992). Estimating Genomic Distance from DNA Sequence Location in Cell Nuclei by a Random Walk Model. Science. https://doi.org/10.1126/science.1388286
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