The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Neutral Salts: The Generality of Their Effects on the Stability of Macromolecular Conformations
Abstract
The effects of various neutral salts on the temperature of the thermally-induced denaturation of the globular protein ribonuclease are described and compared with the effects of these salts on helix-coil transition temperatures in other macromolecules. These agents affect the stability of the native form of macromolecules as diverse as ribonuclease, collagen, DNA, and myosin in very similar ways; salts such as KSCN and CaCl 2 serve as very potent general structural destabilizers or denaturants, while salts such as (NH 4 ) 2 SO 4 and K 2 HPO 4 strongly stabilize the native conformation. The effectiveness of the neutral salts as ribonuclease destabilizers is compared with that of urea and the guanidinium salts.
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Citations
Cites
Activity Coefficients of Nonelectrolyte Solutes in Aqueous Salt Solutions.
Long, F. A., & McDevit, W. F. (1952) · Chemical Reviews · doi:10.1021/cr60158a004 · Cited by 772
The Structure Of Collagen And Gelatin
Harrington, W. F., & Von Hippel, P. H. (1962) · Advances in Protein Chemistry · doi:10.1016/s0065-3233(08)60028-5 · Cited by 399
Self-citationThe Effect of Electrolytes on the Stability of the Deoxyribonucleate Helix
Hamaguchi, K., & Geiduschek, E. P. (1962) · Journal of the American Chemical Society · doi:10.1021/ja00867a001 · Cited by 398
Phase Transitions in Collagen and Gelatin Systems1
Flory, P. J., & Garrett, R. R. (1958) · Journal of the American Chemical Society · doi:10.1021/ja01551a020 · Cited by 336
The Effect of Ions on the Kinetics of Formation and the Stability of the Collagen-Fold*
von Hippel, P. H., & Wong, K.-Y. (1962) · Biochemistry · doi:10.1021/bi00910a020 · Cited by 122
Self-citationBello, J., Riese, H. C. A., & Vinograd, J. R. (1956) · The Journal of Physical Chemistry · doi:10.1021/j150543a035 · Cited by 100
Intramolecular Bonds in Proteins. II. Noncovalent Bonds
Scheraga, H. A. (1963) · Elsevier eBooks · doi:10.1016/b978-0-12-395723-8.50013-1 · Cited by 22
Cited by
Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
Chirgwin, J. M., Przybyla, A. E., MacDonald, R. J., & Rutter, W. J. (1979) · Biochemistry · doi:10.1021/bi00591a005 · Cited by 21,725
Processing of collagen based biomaterials and the resulting materials properties
Meyer, M. (2019) · BioMedical Engineering OnLine · doi:10.1186/s12938-019-0647-0 · Cited by 539
Hofmeister effects: an explanation for the impact of ionic liquids on biocatalysis
Yang, Z. (2009) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2009.04.011 · Cited by 398
Molecular confinement influences protein structure and enhances thermal protein stability
Eggers, D. K., & Valentine, J. S. (2001) · Protein Science · doi:10.1110/ps.36201 · Cited by 393
Metadata
- Authors
- von Hippel, P. H., & Wong, K.-Y.
- Venue
- Science
- Published
- 1964-08-07
- Volume
- 145
- Issue
- 3632
- Pages
- 577-580
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1993588189
- Cited by
- 481
- References
- 7
- FWCI
- 11.75
- Type
- journal article
- Language
- en
- Open access
- closed
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