The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Hydroxyurea: Inhibitory Effect on DNA Metabolism
Abstract
Hydroxyurea, hydroxyurethane, and dihydroxyurea inhibit incorporation of thymidine into the DNA of monolayers of HeLa cells. They do not affect incorporation of uridine into RNA or of leucine into protein. In contrast, hydroxylamine inhibits cellular incorporation of all three precursors: thymidine, uridine, and leucine. Hydroxyurea does not affect thymidine kinase, thymidylate kinase, or DNA polymerase reactions, but it does inhibit incorporation of cytidylic and guanylic acids into DNA in cell-free supernatants.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Thermal Conversion of Nonpriming Deoxyribonucleic Acid to Primer
Bollum, F. J. (1959) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)69770-4 · Cited by 541
Cited by
Studies on the Mechanism of Steroid Hormone Regulation of Synthesis of Specific Proteins
O'MALLEY, B. W., MCGUIRE, W. L., KOHLER, P. O., & KORENMAN, S. G. (1969) · Proceedings of the 1968 Laurentian Hormone Conference · doi:10.1016/b978-0-12-571125-8.50006-5 · Cited by 352
Developmental toxicity of methylamines in mice
Guest, I., & Varma, D. R. (1991) · Journal of Toxicology and Environmental Health · doi:10.1080/15287399109531485 · Cited by 54
Metadata
- Authors
- Young, C. W., & Hodas, S.
- Venue
- Science
- Published
- 1964-11-27
- Volume
- 146
- Issue
- 3648
- Pages
- 1172-1174
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2072089033
- Cited by
- 425
- References
- 1
- FWCI
- 11.03
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Hydroxyurea: Inhibitory Effect on DNA Metabolism. https://app.cochat.ai/papers/10.1126/science.146.3648.1172
- The paper
- Young, C. W., & Hodas, S. (1964). Hydroxyurea: Inhibitory Effect on DNA Metabolism. Science. https://doi.org/10.1126/science.146.3648.1172
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
