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Heparin Enhancement of Factors Stimulating Bone Resorption in Tissue Culture
Abstract
The addition of small amounts of a commercial heparin solution, or a synthetic polysaccharide-sulfuric ester similar in structure to heparin, to the medium in which bone tissue is cultured markedly enhances the amount of bone resorption obtained with suboptimal concentrations of parathyroid extract or other factors which stimulate bone resorption. It is suggested that heparin be considered a "cofactor" which stimulates bone resorption and which may play an important role in physiological or pathological resorption.
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Citations
Cited by
The hypercalcemia of malignancy: Pathogenesis and management
Mundy, G. R., & Martin, T. J. (1982) · Metabolism · doi:10.1016/0026-0495(82)90012-9 · Cited by 311
Skeletal Renewal and Metabolic Bone Disease
Harris, W. H., & Heaney, R. P. (1969) · New England Journal of Medicine · doi:10.1056/nejm196901232800405 · Cited by 278
CARDIAC NERVE LESIONS IN CHAGAS' DISEASE
(1965) · The Lancet · doi:10.1016/s0140-6736(65)90350-8 · Cited by 264
Heparin enhances osteoclastic bone resorption by inhibiting osteoprotegerin activity.
Irie, A., Takami, M., Kubo, H., Sekino-Suzuki, N., Kasahara, K., & Sanai, Y. (2007) · Bone · doi:10.1016/j.bone.2007.04.190 · Cited by 116
Metadata
- Authors
- Goldhaber, P.
- Venue
- Science
- Published
- 1965-01-22
- Volume
- 147
- Issue
- 3656
- Pages
- 407-408
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2015714550
- Cited by
- 179
- References
- 0
- FWCI
- 2.85
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
