The DOI matches its Crossref record.
Base Specificity in the Interaction of Polynucleotides with Antibiotic Drugs
Abstract
Echinomycin, daunomycin, ethidium bromide, nogalamycin, chromomycin, mithramycin, and olivomycin inhibit RNA synthesis by RNA polymerase by interacting with the DNA template. Chromomycin, mithramycin, and olivomycin form complexes with DNA, preferably in the helical form, but not with RNA. These complexes require guanine in DNA and the addition of a stoichiometric amount of bivalent cation. None of the other antibiotics requires the presence of any single base in the template for its action.
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Citations
Cited by
A simple, rapid, and sensitive DNA assay procedure
Labarca, C., & Paigen, K. (1980) · Analytical Biochemistry · doi:10.1016/0003-2697(80)90165-7 · Cited by 4,901
Chaires, J. B., Dattagupta, N., & Crothers, D. M. (1982) · Biochemistry · doi:10.1021/bi00260a005 · Cited by 938
Echinomycin Binding Sites on DNA
Van Dyke, M. M., & Dervan, P. B. (1984) · Science · doi:10.1126/science.6089341 · Cited by 218
Echinomycin: The first bifunctional intercalating agent in clinical trials
Foster, B. J., Clagett-Carr, K., Shoemaker, D. D., Suffness, M., Plowman, J., Trissel, L. A., Grieshaber, C. K., & Leyland-Jones, B. (1985) · Investigational New Drugs · doi:10.1007/bf00170766 · Cited by 61
Gradishar, W. J., Vogelzang, N. J., Kilton, L. J., Leibach, S. J., Rademaker, A. W., French, S., & Benson, A. B. (1995) · Investigational New Drugs · doi:10.1007/bf00872868 · Cited by 49
Metadata
- Authors
- Ward, D. C., Reich, E., & Goldberg, I. H.
- Venue
- Science
- Published
- 1965-09-10
- Volume
- 149
- Issue
- 3689
- Pages
- 1259-1263
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2055213294
- Cited by
- 477
- References
- 0
- FWCI
- 9.73
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ward, D. C., Reich, E., & Goldberg, I. H. (1965). Base Specificity in the Interaction of Polynucleotides with Antibiotic Drugs. Science. https://doi.org/10.1126/science.149.3689.1259
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
