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Histones and Basic Polyamino Acids Stimulate the Uptake of Albumin by Tumor Cells in Culture
Abstract
Basic proteins and polyamino acids are taken up by mammalian cells at rates up to 3000 times greater than serum albumin. When given together with serum albumin they increase the albumin uptake by a factor that correlates with their own rate of uptake and can reach more than 50-fold. The lowest threshold of activity detected (10 -10 M ) is comparable to the activities of the most potent membrane-active agents.
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Citations
Cited by
Structure and properties of pharmacologically active polymers
Ringsdorf, H. (1975) · Journal of Polymer Science: Polymer Symposia · doi:10.1002/polc.5070510111 · Cited by 1,094
Polyarginine enters cells more efficiently than other polycationic homopolymers
Mitchell, D. J., Steinman, L., Kim, D. T., Fathman, C. G., & Rothbard, J. B. (2000) · The Journal of Peptide Research · doi:10.1034/j.1399-3011.2000.00723.x · Cited by 1,084
Heparan sulfate proteoglycan as a cell-surface endocytosis receptor
Christianson, H. C., & Belting, M. (2014) · Matrix Biology · doi:10.1016/j.matbio.2013.10.004 · Cited by 429
Metadata
- Authors
- Ryser, H. J.-P., & Hancock, R.
- Venue
- Science
- Published
- 1965-10-22
- Volume
- 150
- Issue
- 3695
- Pages
- 501-503
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1989019324
- Cited by
- 239
- References
- 0
- FWCI
- 11.11
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Histones and Basic Polyamino Acids Stimulate the Uptake of Albumin by Tumor Cells in Culture. https://app.cochat.ai/papers/10.1126/science.150.3695.501
- The paper
- Ryser, H. J.-P., & Hancock, R. (1965). Histones and Basic Polyamino Acids Stimulate the Uptake of Albumin by Tumor Cells in Culture. Science. https://doi.org/10.1126/science.150.3695.501
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
