The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Circular Dichroism of Biological Macromolecules: Circular dichroism spectra of proteins and nucleic acids provide insights into solution conformations.
Abstract
Circular dichroism, the unequal absorption of right and left circularly polarized light, is a manifestation of optical activity in the vicinity of absorption bands. To the experimental scientist interested in the conformation of macromolecules and in the sensitive response of optical activity to conformational alteration, it offers a relatively new and powerful means of understanding the environment of chromophoric residues. As a tool in the elucidation of electronic spectra, it should be useful to the theoretical scientist in identifying weakly allowed absorption bands as well as in providing rotational parameters which can be compared with the developing theory of optical activity. I have stressed application of circular dichroism, to experimental aspects of protein and nucleic acid conformation in solution. Much is still uncertain in particular quantitative details. However, even these early results shed new light and yield new information on the conformation of these molecules.
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Citations
Cites
Structure of Myoglobin: A Three-Dimensional Fourier Synthesis at 2 Å. Resolution
KENDREW, J. C., DICKERSON, R. E., STRANDBERG, B. E., HART, R. G., DAVIES, D. R., PHILLIPS, D. C., & SHORE, V. C. (1960) · Nature · doi:10.1038/185422a0 · Cited by 1,352
The Ultraviolet Circular Dichroism of Polypeptides1
Holzwarth, G., & Doty, P. (1965) · Journal of the American Chemical Society · doi:10.1021/ja01080a015 · Cited by 1,036
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Optical Rotation And The Conformation Of Polypeptides And Proteins
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A study of conformation of nucleic acids in solution by means of circular dichroism
Brahms, J., & Mommaerts, W. F. H. M. (1964) · Journal of Molecular Biology · doi:10.1016/s0022-2836(64)80029-2 · Cited by 287
Regeneration of Native Secondary and Tertiary Structures by Air Oxidation of Reduced Ribonuclease
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Cited by
Chang, C.-C., Zhao, Z., Li, D., Taylor, A. J., Fan, S., & Chen, H.-T. (2019) · Physical Review Letters · doi:10.1103/physrevlett.123.237401 · Cited by 131
Origin and Role of Optical Isomery in Life
GARAY, A. S. (1968) · Nature · doi:10.1038/219338a0 · Cited by 126
Metadata
- Authors
- Beychok, S.
- Venue
- Science
- Published
- 1966-12-09
- Volume
- 154
- Issue
- 3754
- Pages
- 1288-1299
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2039598741
- Cited by
- 375
- References
- 14
- FWCI
- 14.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- Beychok, S. (1966). Circular Dichroism of Biological Macromolecules: Circular dichroism spectra of proteins and nucleic acids provide insights into solution conformations. Science. https://doi.org/10.1126/science.154.3754.1288
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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