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HLA-A2.1-Associated Peptides from a Mutant Cell Line: A Second Pathway of Antigen Presentation
Abstract
Peptides extracted from HLA-A2.1 class I major histocompatibility complex (MHC) molecules expressed on the antigen processing mutant CEMx721.174.T2 were characterized by electrospray ionization-tandem mass spectrometry. Only seven dominant peptides were found, in contrast to over 200 associated with HLA-A2.1 on normal cells. These peptides were derived from the signal peptide domains of normal cellular proteins, were usually larger than nine residues, and were also associated with HLA-A2.1 in normal cells. These results suggest that proteolysis of signal peptide domains in the endoplasmic reticulum is a second mechanism for processing and presentation of peptides for association with class I molecules.
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Citations
Cited by
Eng, J. K., McCormack, A. L., & Yates, J. R. (1994) · Journal of the American Society for Mass Spectrometry · doi:10.1016/1044-0305(94)80016-2 · Cited by 6,484
MHC ligands and peptide motifs: first listing
Rammensee, H.-G., Friede, T., & Stevanović, S. (1995) · Immunogenetics · doi:10.1007/bf00172063 · Cited by 1,638
Restifo, N. P., Marincola, F. M., Kawakami, Y., Taubenberger, J., Yannelli, J. R., & Rosenberg, S. A. (1996) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/88.2.100 · Cited by 533
The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP
Ahn, K., Gruhler, A., Galocha, B., Jones, T. R., Wiertz, E. J. H. J., Ploegh, H. L., Peterson, P. A., Yang, Y., & Früh, K. (1997) · Immunity · doi:10.1016/s1074-7613(00)80349-0 · Cited by 477
Two tyrosinase nonapeptides recognized on HLA‐A2 melanomas by autologous cytolytic T lymphocytes
Wölfel, T., Van Pel, A., Brichard, V., Schneider, J., Seliger, B., Zum Büschenfelde, K. M., & Boon, T. (1994) · European Journal of Immunology · doi:10.1002/eji.1830240340 · Cited by 411
Metadata
- Authors
- Henderson, R. A., Michel, H., Sakaguchi, K., Shabanowitz, J., Appella, E., Hunt, D. F., & Engelhard, V. H.
- Venue
- Science
- Published
- 1992-03-06
- Volume
- 255
- Issue
- 5049
- Pages
- 1264-1266
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2077861376
- Cited by
- 520
- References
- 0
- FWCI
- 19.09
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: HLA-A2.1-Associated Peptides from a Mutant Cell Line: A Second Pathway of Antigen Presentation. https://app.cochat.ai/papers/10.1126/science.1546329
- The paper
- Henderson, R. A., Michel, H., Sakaguchi, K., Shabanowitz, J., Appella, E., Hunt, D. F., & Engelhard, V. H. (1992). HLA-A2.1-Associated Peptides from a Mutant Cell Line: A Second Pathway of Antigen Presentation. Science. https://doi.org/10.1126/science.1546329
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
