The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Biological Significance of Unwinding Capability of Nuclear Matrix-Associating DNAs
Abstract
Matrix attachment regions (MARs) are thought to separate chromatin into topologically constrained loop domains. A MAR located 5′ of the human β-interferon gene becomes stably base-unpaired under superhelical strain, as do the MARs flanking the immunoglobulin heavy chain gene enhancer; in both cases a nucleation site exists for DNA unwinding. Concatemerized oligonucleotides containing the unwinding nucleation site exhibited a strong affinity for the nuclear scaffold and augmented SV40 promoter activity in stable transformants. Mutated concatemerized oligonucleotides resisted unwinding, showed weak affinity for the nuclear scaffold, and did not enhance promoter activity. These results suggest that the DNA feature capable of relieving superhelical strain is important for MAR functions.
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Cites
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Nanoparticle-based technologies for retinal gene therapy
Adijanto, J., & Naash, M. I. (2015) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2014.12.028 · Cited by 107
High-level transgene expression by homologous recombination-mediated gene transfer
Grandjean, M., Girod, P.-A., Calabrese, D., Kostyrko, K., Wicht, M., Yerly, F., Mazza, C., Beckmann, J. S., Martinet, D., & Mermod, N. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr436 · Cited by 53
Molecular characterization of a human matrix attachment region epigenetic regulator
Arope, S., Harraghy, N., Pjanic, M., & Mermod, N. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079262 · Cited by 39
Xu, Z., Chen, F., Zhang, L., Lu, J., Xu, P., Liu, G., Xie, X., Mu, W., Wang, Y., & Liu, D. (2016) · Science China Life Sciences · doi:10.1007/s11427-016-0067-0 · Cited by 20
Metadata
- Authors
- Bode, J., Kohwi, Y., Dickinson, L., Joh, T., Klehr, D., Mielke, C., & Kohwi-Shigematsu, T.
- Venue
- Science
- Published
- 1992-01-10
- Volume
- 255
- Issue
- 5041
- Pages
- 195-197
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2037539600
- Cited by
- 406
- References
- 30
- FWCI
- 7.89
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bode, J., Kohwi, Y., Dickinson, L., Joh, T., Klehr, D., Mielke, C., & Kohwi-Shigematsu, T. (1992). Biological Significance of Unwinding Capability of Nuclear Matrix-Associating DNAs. Science. https://doi.org/10.1126/science.1553545
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
