Regeneration of Rat Liver: Transfer of Humoral Agent by Cross Circulation
Abstract
Carotid-to-jugular cross circulation between partially hepatectomized and normal rats, via polyethylene cannulas, stimulated incorporation of (14)C-thymidine into hepatic DNA in the normal partners when it was maintained for 19 hours at a flow rate of about 2 milliliters per minute. Cross circulation for 7 hours or less was ineffective.
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In experiments where the portal circulations of two animals are connected via a shunt, hepatectomy in one animal induces liver growth in the other, despite the absence of direct liver tissue damage.
“Moreover, in experiments where the portal circulations of two animals are connected via a shunt, hepatectomy in one animal induces liver growth in the other, despite the absence of direct liver tissue damage[40,41].”
From Liver regeneration after partial hepatectomy: Triggers and mechanisms (2025) · cites this paper as [41]
Mitogenic signals for hepatocytes are transported in the blood and induce immediate early genes within 30 minutes after partial hepatectomy.
“Convincing evidence has been found that mitogenic signals for hepatocytes are transported in the blood 2,3 and that they induce a number of immediate early genes within 30 minutes after PH. 4”
From Interleukin 6 Is Important for Survival After Partial Hepatectomy in Mice (2003) · cites this paper as [3]
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References 10 · Cited by 277
- Authors
- Moolten, F. L., & Bucher, N. L. R.
- Affiliations
- Harvard University (US)
- Venue
- Science
- Published
- 1967-10-13
- Volume
- 158
- Issue
- 3798
- Pages
- 272-274
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2047164219
- Cited by
- 277
- References
- 10
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 5 · 2023: 2 · 2021: 3 · 2020: 8 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 2 · 2015: 9 · 2014: 5 · 2013: 8 · 2012: 6
- FWCI
- 14.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- liver regeneration, partial hepatectomy, humoral factors, cross-circulation, thymidine incorporation, hepatic DNA synthesis, rat liver
- MeSH terms
- Animals, Carbon Isotopes, DNA, Female, Hepatectomy, Liver, Liver Regeneration, Mitosis, Parabiosis, Thymidine, Rats
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