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Oxytocin Gene Expression in Rat Uterus
Abstract
The neurohypophyseal hormone oxytocin (OT) is the most potent uterotonic agent known and is used to induce labor. Yet, endogenous circulating OT appears not to participate in the induction of labor. As shown here, the finding of OT messenger RNA and peptide in the uterus suggests a solution for this paradox. During gestation, rat uterus OT messenger RNA increased more than 150-fold and, at term, exceeded hypothalamic OT messenger RNA by 70-fold. Thus, during parturition, OT may act primarily as a local mediator and not as a circulating hormone.
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Cited by
The oxytocin receptor system: structure, function, and regulation
Gimpl, G., & Fahrenholz, F. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.629 · Cited by 3,089
The oxytocin receptor: from intracellular signaling to behavior
Jurek, B., & Neumann, I. D. (2018) · Physiological Reviews · doi:10.1152/physrev.00031.2017 · Cited by 999
Endocrine and Paracrine Regulation of Birth at Term and Preterm*
Challis, J. R. G., Matthews, S. G., Gibb, W., & Lye, S. J. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.5.0407 · Cited by 995
Luteolysis: A Neuroendocrine-Mediated Event
McCracken, J. A., Custer, E. E., & Lamsa, J. C. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.2.263 · Cited by 757
Oxytocin is required for nursing but is not essential for parturition or reproductive behavior.
Nishimori, K., Young, L. J., Guo, Q., Wang, Z., Insel, T. R., & Matzuk, M. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.11699 · Cited by 734
Metadata
- Authors
- Lefebvre, D. L., Giaid, A., Bennett, H., Larivière, R., & Zingg, H. H.
- Venue
- Science
- Published
- 1992-06-12
- Volume
- 256
- Issue
- 5063
- Pages
- 1553-1555
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2017890520
- Cited by
- 173
- References
- 0
- FWCI
- 34.66
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lefebvre, D. L., Giaid, A., Bennett, H., Larivière, R., & Zingg, H. H. (1992). Oxytocin Gene Expression in Rat Uterus. Science. https://doi.org/10.1126/science.1598587
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
