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Differentiated Rat Glial Cell Strain in Tissue Culture
Abstract
Rat glial tumors, induced by injections of N -nitrosomethylurea, were plated and propagated in culture. Among a few cell strains obtained, one clone contains S-100 protein, which is unique to brain in vertebrates. Stationary-phase cultures contain approximately ten times more S-100 protein per cell than exponentially growing cells. When injected into newborn rats, cells producing S-100 grew as a glial tumor, which contained S-100 protein.
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Cited by
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Shweiki, D., Itin, A., Soffer, D., & Keshet, E. (1992) · Nature · doi:10.1038/359843a0 · Cited by 4,617
Shweiki, D., Neeman, M., Itin, A., & Keshet, E. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.3.768 · Cited by 599
αB-crystallin is expressed in non-lenticular tissues and accumulates in Alexander's disease brain
Iwaki, T., Kume-Iwaki, A., Liem, R. K. H., & Goldman, J. E. (1989) · Cell · doi:10.1016/0092-8674(89)90173-6 · Cited by 549
Stein, I., Neeman, M., Shweiki, D., Itin, A., & Keshet, E. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.10.5363 · Cited by 455
Barth, R. F., & Kaur, B. (2009) · Journal of Neuro-Oncology · doi:10.1007/s11060-009-9875-7 · Cited by 427
Metadata
- Authors
- Benda, P., Lightbody, J., Sato, G., Levine, L., & Sweet, W.
- Venue
- Science
- Published
- 1968-07-26
- Volume
- 161
- Issue
- 3839
- Pages
- 370-371
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1990918868
- Cited by
- 1,472
- References
- 0
- FWCI
- 9.12
- Type
- journal article
- Language
- en
- Open access
- closed
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- Benda, P., Lightbody, J., Sato, G., Levine, L., & Sweet, W. (1968). Differentiated Rat Glial Cell Strain in Tissue Culture. Science. https://doi.org/10.1126/science.161.3839.370
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
