The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Morphine Tolerance, Physical Dependence, and Synthesis of Brain 5-Hydroxytryptamine
Abstract
Tolerance and physical dependence development to morphine in mice can be prevented by concomitant administration of cycloheximide. The fact that the rate of synthesis of brain 5-hydroxytryptamine (5HT) increases with tolerance to morphine suggests that the protein involved may be associated with 5HT synthesis. Inhibition of this synthesis with p -chlorophenylalanine markedly decreases tolerance and physical dependence development to morphine.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A SIMPLIFIED METHOD OF EVALUATING DOSE-EFFECT EXPERIMENTS
LITCHFIELD, J. T., & WILCOXON, F. (1949) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)03549-9 · Cited by 7,812
p-CHLOROPHENYLALANINE: A SPECIFIC DEPLETOR OF BRAIN SEROTONIN
Koe, B. K., & Weissman, A. (1966) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)27497-3 · Cited by 1,783
JÉQUIER, E., LOVENBERG, W., & SJOERDSMA, A. (1967) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)14792-5 · Cited by 422
Tozer, T. N., Neff, N. H., & Brodie, B. B. (1966) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)27378-5 · Cited by 313
TOLERANCE TO MORPHINE. I. EFFECTS ON CATECHOLAMINES IN THE BRAIN AND ADRENAL GLANDS
Maynert, E. W., & Klingman, G. I. (1962) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)26233-4 · Cited by 144
Tolerance to morphine. II. Lack of effects on brain 5-hydroxytryptamine and gamma-aminobutyric acid.
Maynert, E. W., Klingman, G. I., & Kaji, H. K. (1962) · PubMed · Cited by 83
Gunne, L. (1959) · Nature · doi:10.1038/1841950a0 · Cited by 66
Sloan, J. W., Brooks, J. W., Eisenman, A. J., & Martin, W. R. (1963) · Psychopharmacology · doi:10.1007/bf00408181 · Cited by 57
Cited by
Protein synthesis and memory: A review.
Davis, H. P., & Squire, L. R. (1984) · Psychological Bulletin · doi:10.1037//0033-2909.96.3.518 · Cited by 1,503
Mu Opioids and Their Receptors: Evolution of a Concept
Pasternak, G. W., & Pan, Y.-X. (2013) · Pharmacological Reviews · doi:10.1124/pr.112.007138 · Cited by 578
μ Opioid receptor knockout in mice: effects on ligand-induced analgesia and morphine lethality
Loh, H. H., Liu, H.-C., Cavalli, A., Yang, W., Chen, Y.-F., & Wei, L.-N. (1998) · Molecular Brain Research · doi:10.1016/s0169-328x(97)00353-7 · Cited by 337
Self-citationMonahan, J. B., Handelmann, G. E., Hood, W. F., & Cordi, A. A. (1989) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(89)90571-6 · Cited by 257
Tilson, H. A., Rech, R. H., & Stolman, S. (1973) · Psychopharmacologia · doi:10.1007/bf00429309 · Cited by 107
Metadata
- Authors
- Way, E. L., Loh, H. H., & Shen, F.-H.
- Venue
- Science
- Published
- 1968-12-13
- Volume
- 162
- Issue
- 3859
- Pages
- 1290-1292
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2154084570
- Cited by
- 256
- References
- 8
- FWCI
- 10.63
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Morphine Tolerance, Physical Dependence, and Synthesis of Brain 5-Hydroxytryptamine. https://app.cochat.ai/papers/10.1126/science.162.3859.1290
- The paper
- Way, E. L., Loh, H. H., & Shen, F.-H. (1968). Morphine Tolerance, Physical Dependence, and Synthesis of Brain 5-Hydroxytryptamine. Science. https://doi.org/10.1126/science.162.3859.1290
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
