The DOI matches its Crossref record.
Differing Lymphokine Profiles of Functional Subsets of Human CD4 and CD8 T Cell Clones
Abstract
Functional subsets of human T cells were delineated by analyzing patterns of lymphokines produced by clones from individuals with leprosy and by T cell clones of known function. CD4 clones from individuals with strong cell-mediated immunity produced predominantly interferon-γ, whereas those clones that enhanced antibody formation produced interleukin-4. CD8 cytotoxic T cells secreted interferon-γ. Interleukin-4 was produced by CD8 T suppressor clones from immunologically unresponsive individuals with leprosy and was found to be necessary for suppression in vitro. Both the classic reciprocal relation between antibody formation and cell-mediated immunity and resistance or susceptibility to certain infections may be explained by T cell subsets differing in patterns of lymphokine production.
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Cited by
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Nakanishi, K., Yoshimoto, T., Tsutsui, H., & Okamura, H. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.423 · Cited by 1,315
Szabo, P. A., Levitin, H. M., Miron, M., Snyder, M. E., Senda, T., Yuan, J., Cheng, Y. L., Bush, E. C., Dogra, P., Thapa, P., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12464-3 · Cited by 756
Steinbrink, K., Graulich, E., Kubsch, S., Knop, J., & Enk, A. H. (2002) · Blood · doi:10.1182/blood.v99.7.2468 · Cited by 448
Reversibility of T helper 1 and 2 populations is lost after long-term stimulation.
Murphy, E., Shibuya, K., Hosken, N., Openshaw, P., Maino, V, Davis, K., Murphy, K., & O'Garra, A. (1996) · The Journal of experimental medicine · doi:10.1084/jem.183.3.901 · Cited by 435
Cytokine production at the site of disease in human tuberculosis
Barnes, P. F., Lu, S., Abrams, J. S., Wang, E., Yamamura, M., & Modlin, R. L. (1993) · Infection and Immunity · doi:10.1128/iai.61.8.3482-3489.1993 · Cited by 371
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Metadata
- Authors
- Salgame, P., Abrams, J. S., Clayberger, C., Goldstein, H., Convit, J., Modlin, R. L., & Bloom, B. R.
- Venue
- Science
- Published
- 1991-10-11
- Volume
- 254
- Issue
- 5029
- Pages
- 279-282
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1966333025
- Cited by
- 1,028
- References
- 0
- FWCI
- 31.96
- Type
- journal article
- Language
- en
- Open access
- closed
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- Salgame, P., Abrams, J. S., Clayberger, C., Goldstein, H., Convit, J., Modlin, R. L., & Bloom, B. R. (1991). Differing Lymphokine Profiles of Functional Subsets of Human CD4 and CD8 T Cell Clones. Science. https://doi.org/10.1126/science.1681588
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
