The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Functional Evidence for an RNA Template in Telomerase
Abstract
The RNA moiety of the ribonucleoprotein enzyme telomerase from the ciliate Euplotes crassus was identified and its gene was sequenced. Functional analysis, in which oligonucleotides complementary to portions of the telomerase RNA were tested for their ability to prime telomerase in vitro, showed that the sequence 5′ CAAAACCCCAAA 3′ in this RNA is the template for synthesis of telomeric TTTTGGGG repeats by the Euplotes telomerase. The data provide a direct demonstration of a template function for a telomerase RNA and demarcate the outer boundaries of the telomeric template. Telomerase can now be defined as a specialized reverse transcriptase.
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Citations
Cites
A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis
Greider, C. W., & Blackburn, E. H. (1989) · Nature · doi:10.1038/337331a0 · Cited by 1,643
Self-citationMorin, G. B. (1989) · Cell · doi:10.1016/0092-8674(89)90035-4 · Cited by 1,495
Greider, C. W., & Blackburn, E. H. (1987) · Cell · doi:10.1016/0092-8674(87)90576-9 · Cited by 1,150
Cited by
Structure and function of telomeres
Blackburn, E. H. (1991) · Nature · doi:10.1038/350569a0 · Cited by 3,596
Self-citationThe RNA Component of Human Telomerase
Feng, J., Funk, W. D., Wang, S.-S., Weinrich, S. L., Avilion, A. A., Chiu, C.-P., Adams, R. R., Chang, E., Allsopp, R. C., Yu, J., et al. (1995) · Science · doi:10.1126/science.7544491 · Cited by 2,227
Reverse Transcriptase Motifs in the Catalytic Subunit of Telomerase
Lingner, J., Hughes, T. R., Shevchenko, A., Mann, M., Lundblad, V., & Cech, T. R. (1997) · Science · doi:10.1126/science.276.5312.561 · Cited by 1,269
An alternative pathway for yeast telomere maintenance rescues est1− senescence
Lundblad, V., & Blackburn, E. H. (1993) · Cell · doi:10.1016/0092-8674(93)90234-h · Cited by 942
Self-citationRibosome Profiling Provides Evidence that Large Noncoding RNAs Do Not Encode Proteins
Guttman, M., Russell, P., Ingolia, N. T., Weissman, J. S., & Lander, E. S. (2013) · Cell · doi:10.1016/j.cell.2013.06.009 · Cited by 745
Metadata
- Authors
- Shippen-Lentz, D., & Blackburn, E. H.
- Venue
- Science
- Published
- 1990-02-02
- Volume
- 247
- Issue
- 4942
- Pages
- 546-552
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2069337628
- Cited by
- 382
- References
- 3
- FWCI
- 14.82
- Type
- journal article
- Language
- en
- Open access
- closed
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