The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Cyclic Adenosine Monophosphate in Bacteria: In many bacteria the synthesis of inducible enzymes requires this cyclic nucleotide.
Abstract
Both cyclic AMP and a specific inducer acting in concert are required for the synthesis of many inducible enzymes in E. coli. Little enzyme is made in the absence of either. In contrast to the specific inducers which stimulate the synthesis only of the proteins required for their metabolism, cyclic AMP controls the synthesis of many proteins. Glucose and certain other carbohydrates decrease the differential rate of synthesis of inducible enzymes by lowering cyclic AMP concentrations. In the lac operon, cyclic AMP acts at the promoter site to facilitate initiation of transcription. This action requires another protein, the cyclic AMP receptor protein. The nucleotide stimulates tryptophanase synthesis at a translational level. The action of cyclic AMP in E. coli may serve as a model to understand its action on transcriptional and translational processes in eukaryotes.
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Citations
Cites
Genetic regulatory mechanisms in the synthesis of proteins.
Jacob, F., & Monod, J. (1961) · Journal of Molecular Biology · doi:10.1016/s0022-2836(61)80072-7 · Cited by 5,300
A quantitative assay for DNA-RNA hybrids with DNA immobilized on a membrane
Gillespie, D., & Spiegelman, S. (1965) · Journal of Molecular Biology · doi:10.1016/s0022-2836(65)80331-x · Cited by 1,964
Robinson, G. A., Butcher, R. W., & Sutherland, E. W. (1968) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.37.070168.001053 · Cited by 958
ISOLATION OF THE LAC REPRESSOR
Gilbert, W., & Müller-Hill, B. (1966) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.56.6.1891 · Cited by 654
PHOSPHATE BOUND TO HISTIDINE IN A PROTEIN AS AN INTERMEDIATE IN A NOVEL PHOSPHO-TRANSFERASE SYSTEM
Kundig, W., Ghosh, S., & Roseman, S. (1964) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.52.4.1067 · Cited by 614
Magasanik, B. (1961) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1961.026.01.031 · Cited by 535
Adenosine 3‘,5‘-Phosphate in Escherichia coli
Makman, R. S., & Sutherland, E. W. (1965) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)97576-9 · Cited by 458
Mode of action of rifamycin on the RNA polymerase reaction
Sippel, A., & Hartmann, G. (1968) · Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis · doi:10.1016/0005-2787(68)90286-4 · Cited by 355
Cyclic AMP Receptor Protein of E. coli: Its Role in the Synthesis of Inducible Enzymes
Emmer, M., deCrombrugghe, B., Pastan, I. H., & Perlman, R. L. (1970) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.66.2.480 · Cited by 329
Self-citationGilbert, W., & Müller-Hill, B. (1967) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.58.6.2415 · Cited by 303
Cited by
Structure and function of adenylyl cyclases, key enzymes in cellular signaling
Khannpnavar, B., Mehta, V., Qi, C., & Korkhov, V. (2020) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2020.03.003 · Cited by 77
Metadata
- Authors
- Pastan, I., & Perlman, R.
- Venue
- Science
- Published
- 1970-07-24
- Volume
- 169
- Issue
- 3943
- Pages
- 339-344
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1996446016
- Cited by
- 503
- References
- 30
- FWCI
- 68.68
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
