The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
External Guide Sequences for an RNA Enzyme
Abstract
Ribonuclease P (RNase P) from Escherichia coli or its catalytic RNA subunit can efficiently cleave small RNA substrates that lack the conserved features of natural substrates of RNase P if an additional small RNA is also present. This additional RNA must contain a sequence complementary to the substrate [external guide sequence (EGS)] and a 3′-proximal CCA sequence to ensure cleavage. The aminoacyl acceptor stem and some additional 5′- and 3′-terminal sequences of a precursor transfer RNA are sufficient to allow efficient cleavage by RNase P, and the 2′-hydroxyl group at the cleavage site is not absolutely necessary for cleavage. In principle, any RNA could be targeted by a custom-designed EGS RNA for specific cleavage by RNase P in vitro or in vivo.
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Cites
The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme
Guerrier-Takada, C., Gardiner, K., Marsh, T., Pace, N., & Altman, S. (1983) · Cell · doi:10.1016/0092-8674(83)90117-4 · Cited by 2,684
Self-citationOligoribonucleotide synthesis using T7 RNA polymerase and synthetic DNA templates
Milligan, J. F., Groebe, D. R., Witherell, G. W., & Uhlenbeck, O. C. (1987) · Nucleic Acids Research · doi:10.1093/nar/15.21.8783 · Cited by 2,136
Selection in vitro of an RNA enzyme that specifically cleaves single-stranded DNA
Robertson, D. L., & Joyce, G. F. (1990) · Nature · doi:10.1038/344467a0 · Cited by 1,331
Simple RNA enzymes with new and highly specific endoribonuclease activities
Haseloff, J., & Gerlach, W. L. (1988) · Nature · doi:10.1038/334585a0 · Cited by 1,103
Self-cleavage of plus and minus RNAs of a virusoid and a structural model for the active sites
Forster, A. C., & Symons, R. H. (1987) · Cell · doi:10.1016/0092-8674(87)90562-9 · Cited by 666
Self-citationRibozymes as Potential Anti-HIV-1 Therapeutic Agents
Sarver, N., Cantin, E. M., Chang, P. S., Zaia, J. A., Ladne, P. A., Stephens, D. A., & Rossi, J. J. (1990) · Science · doi:10.1126/science.2107573 · Cited by 658
Blum, B., Bakalara, N., & Simpson, L. (1990) · Cell · doi:10.1016/0092-8674(90)90735-w · Cited by 575
Comparison of fungal mitochondrial introns reveals extensive homologies in RNA secondary structure
Michel, F., Jacquier, A., & Dujon, B. (1982) · Biochimie · doi:10.1016/s0300-9084(82)80349-0 · Cited by 496
Making ends meet: a model for RNA splicing in fungal mitochondria
Davies, R. W., Waring, R. B., Ray, J. A., Brown, T. A., & Scazzocchio, C. (1982) · Nature · doi:10.1038/300719a0 · Cited by 456
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Lu, Y., Berry, S. M., & Pfister, T. D. (2001) · Chemical Reviews · doi:10.1021/cr0000574 · Cited by 375
Highly Efficient Self-Replicating RNA Enzymes
Robertson, M. P., & Joyce, G. F. (2014) · Chemistry & Biology · doi:10.1016/j.chembiol.2013.12.004 · Cited by 105
Kinetic properties of an RNA enzyme that undergoes self-sustained exponential amplification
Ferretti, A. C., & Joyce, G. F. (2013) · Biochemistry · doi:10.1021/bi301646n · Cited by 33
Metadata
- Authors
- Forster, A. C., & Altman, S.
- Venue
- Science
- Published
- 1990-08-17
- Volume
- 249
- Issue
- 4970
- Pages
- 783-786
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2080036688
- Cited by
- 309
- References
- 30
- FWCI
- 4.86
- Type
- journal article
- Language
- en
- Open access
- closed
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
