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Specific Inhibition of Nuclear RNA Polymerase II by α-Amanitin
Abstract
α-Amanitin, a toxic substance from the mushroom Amanita phalloides , is a potent inhibitor of DNA-dependent RNA polymerase II (the nucleoplasmic form) from sea urchin, rat liver, and calf thymus. This compound exerts no effect on the activity of polymerase I (nucleolar form) or polymerase III (also nucleoplasmic). The inhibition is due to a specific interaction with polymerase II or with a complex of DNA and polymerase II.
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Metadata
- Authors
- Lindell, T. J., Weinberg, F., Morris, P. W., Roeder, R. G., & Rutter, W. J.
- Venue
- Science
- Published
- 1970-10-23
- Volume
- 170
- Issue
- 3956
- Pages
- 447-449
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1967946050
- Cited by
- 866
- References
- 0
- FWCI
- 24.82
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lindell, T. J., Weinberg, F., Morris, P. W., Roeder, R. G., & Rutter, W. J. (1970). Specific Inhibition of Nuclear RNA Polymerase II by α-Amanitin. Science. https://doi.org/10.1126/science.170.3956.447
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
