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Plasminogen: Purification from Human Plasma by Affinity Chromatography
Abstract
Plasminogen was prepared from human plasma by affinity chromatography on L-lysine-substituted Sepharose. Thirty milligrams of plasminogen, with a specific activity of 100 caseinolytic units (Committee on Thrombolytic Agents) per milligram of nitrogen, were obtained from 340 milliliters of plasma. This corresponds to over 200-fold purification from plasma. Disc-gel electrophoresis at p H 8.3 indicated seven distinct bands, all of which contained activity.
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Cited by
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O'Reilly, M. S., Boehm, T., Shing, Y., Fukai, N., Vasios, G., Lane, W. S., Flynn, E., Birkhead, J. R., Olsen, B. R., & Folkman, J. (1997) · Cell · doi:10.1016/s0092-8674(00)81848-6 · Cited by 4,486
Kinetics of the activation of plasminogen by human tissue plasminogen activator. Role of fibrin.
Hoylaerts, M., Rijken, D. C., Lijnen, H. R., & Collen, D. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)81051-7 · Cited by 1,312
A study of proteases and protease-inhibitor complexes in biological fluids
Granelli-Piperno, A., & Reich, E. (1978) · The Journal of Experimental Medicine · doi:10.1084/jem.148.1.223 · Cited by 803
Plasminogen activator in early embryogenesis: Enzyme production by trophoblast and parietal endoderm
Strickland, S., Reich, E., & Sherman, M. I. (1976) · Cell · doi:10.1016/0092-8674(76)90114-8 · Cited by 580
Saksela, O., & Rifkin, D. B. (1990) · The Journal of cell biology · doi:10.1083/jcb.110.3.767 · Cited by 539
Metadata
- Authors
- Deutsch, D. G., & Mertz, E. T.
- Venue
- Science
- Published
- 1970-12-04
- Volume
- 170
- Issue
- 3962
- Pages
- 1095-1096
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2012839797
- Cited by
- 2,130
- References
- 0
- FWCI
- 27.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- Deutsch, D. G., & Mertz, E. T. (1970). Plasminogen: Purification from Human Plasma by Affinity Chromatography. Science. https://doi.org/10.1126/science.170.3962.1095
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
