The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Generation of cAMP-Activated Chloride Currents by Expression of CFTR
Abstract
Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) cause cystic fibrosis. In order to evaluate its function, CFTR was expressed in HeLa, Chinese hamster ovary (CHO), and NIH 3T3 fibroblast cells, and anion permeability was assessed with a fluorescence microscopic assay and the whole-cell patch-clamp technique. Adenosine 3′,5′-monophosphate (cAMP) increased anion permeability and chloride currents in cells expressing CFTR, but not in cells expressing a mutant CFTR (ΔF508) or in nontransfected cells. The simplest interpretation of these observations is that CFTR is itself a cAMP-activated chloride channel. The alternative interpretation, that CFTR directly or indirectly regulates chloride channels, requires that these cells have endogenous cryptic, chloride channels that are stimulated by cAMP only in the presence of CFTR.
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Hamill, O. P., Marty, A., Neher, E., Sakmann, B., & Sigworth, F. J. (1981) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00656997 · Cited by 18,436
Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA
Riordan, J. R., Rommens, J. M., Kerem, B.-S., Alon, N., Rozmahel, R., Grzelczak, Z., Zielenski, J., Lok, S., Plavsic, N., Chou, J.-L., et al. (1989) · Science · doi:10.1126/science.2475911 · Cited by 7,418
Identification of the Cystic Fibrosis Gene: Genetic Analysis
Kerem, B.-S., Rommens, J. M., Buchanan, J. A., Markiewicz, D., Cox, T. K., Chakravarti, A., Buchwald, M., & Tsui, L.-C. (1989) · Science · doi:10.1126/science.2570460 · Cited by 4,142
Cited by
Lung Infections Associated with Cystic Fibrosis
Lyczak, J. B., Cannon, C. L., & Pier, G. B. (2002) · Clinical Microbiology Reviews · doi:10.1128/cmr.15.2.194-222.2002 · Cited by 1,628
Processing of mutant cystic fibrosis transmembrane conductance regulator is temperature-sensitive
Denning, G. M., Anderson, M. P., Amara, J. F., Marshall, J., Smith, A. E., & Welsh, M. J. (1992) · Nature · doi:10.1038/358761a0 · Cited by 1,234
Self-citationStructure and Function of the CFTR Chloride Channel
SHEPPARD, D. N., & WELSH, M. J. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.1.s23 · Cited by 1,018
Self-citationRosenfeld, M. A., Yoshimura, K., Trapnell, B. C., Yoneyama, K., Rosenthal, E. R., Dalemans, W., Fukayama, M., Bargon, J., Stier, L. E., Stratford-Perricaudet, L., et al. (1992) · Cell · doi:10.1016/0092-8674(92)90213-v · Cited by 931
Altered chloride ion channel kinetics associated with the ΔF508 cystic fibrosis mutation
Dalemans, W., Barbry, P., Champigny, G., Jallat, S., Jallat, S., Dott, K., Dreyer, D., Crystal, R. G., Pavirani, A., Lecocq, J.-P., et al. (1991) · Nature · doi:10.1038/354526a0 · Cited by 707
Metadata
- Authors
- Anderson, M. P., Rich, D. P., Gregory, R. J., Smith, A. E., & Welsh, M. J.
- Venue
- Science
- Published
- 1991-02-08
- Volume
- 251
- Issue
- 4994
- Pages
- 679-682
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1982071077
- Cited by
- 550
- References
- 3
- FWCI
- 101.77
- Type
- journal article
- Language
- en
- Open access
- closed
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- Anderson, M. P., Rich, D. P., Gregory, R. J., Smith, A. E., & Welsh, M. J. (1991). Generation of cAMP-Activated Chloride Currents by Expression of CFTR. Science. https://doi.org/10.1126/science.1704151
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