The DOI matches its Crossref record.
Cyclic Adenosine Monophosphate and Norepinephrine: Effects on Transmembrane Properties of Cerebellar Purkinje Cells
Abstract
Electrical properties of Purkinje cells were recorded by intracellular microelectrode during extracellular electrophoretic application of gamma aminobutyrate, norepinephrine, cyclic adenosine monophosphate, and dibutyryl cyclic adenosine monophosphate. All these substances hyperpolarized Purkinje cells. Transmembrane resistance decreased during gamma aminobutyrate hyperpolarization. In contrast, norepinephrine and the cyclic nucleotides generally elevated resistance. These results show that cyclic nucleotides mimic the unique effects of norepinephrine on the bioelectric properties of neuronal membranes.
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Citations
Cited by
Greengard, P. (1976) · Nature · doi:10.1038/260101a0 · Cited by 694
NISTRI, A., & CONSTANTI, A. (1979) · Progress in Neurobiology · doi:10.1016/0301-0082(79)90016-9 · Cited by 395
Madison, D. V., & Nicoll, R. A. (1986) · The Journal of Physiology · doi:10.1113/jphysiol.1986.sp016006 · Cited by 391
Antagonism between bicuculline and GABA in the cat brain
Curtis, D. R., Duggan, A. W., Felix, D., Johnston, G. A. R., & McLennan, H. (1971) · Brain Research · doi:10.1016/0006-8993(71)90305-2 · Cited by 364
Metadata
- Authors
- Siggins, G. R., Oliver, A. P., Hoffer, B. J., & Bloom, F. E.
- Venue
- Science
- Published
- 1971-01-15
- Volume
- 171
- Issue
- 3967
- Pages
- 192-194
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2094878156
- Cited by
- 237
- References
- 0
- FWCI
- 8.78
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Cyclic Adenosine Monophosphate and Norepinephrine: Effects on Transmembrane Properties of Cerebellar Purkinje Cells. https://app.cochat.ai/papers/10.1126/science.171.3967.192
- The paper
- Siggins, G. R., Oliver, A. P., Hoffer, B. J., & Bloom, F. E. (1971). Cyclic Adenosine Monophosphate and Norepinephrine: Effects on Transmembrane Properties of Cerebellar Purkinje Cells. Science. https://doi.org/10.1126/science.171.3967.192
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
