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Structural Features that Give Rise to the Unusual Stability of RNA Hairpins Containing GNRA Loops
Abstract
The most frequently occurring RNA hairpins in 16 S and 23 S ribosomal RNA contain a tetranucleotide loop that has a GNRA consensus sequence. The solution structures of the GCAA and GAAA hairpins have been determined by nuclear magnetic resonance spectroscopy. Both loops contain an unusual G-A base pair between the first and last residue in the loop, a hydrogen bond between a G base and a phosphate, extensive base stacking, and a hydrogen bond between a sugar 2′-end OH and a base. These interactions explain the high stability of these hairpins and the sequence requirements for the variant and invariant nucleotides in the GNRA tetranucleotide loop family.
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Cited by
Adaptive Recognition by Nucleic Acid Aptamers
Hermann, T., & Patel, D. J. (2000) · Science · doi:10.1126/science.287.5454.820 · Cited by 1,650
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Leontis, N. B. (2002) · Nucleic Acids Research · doi:10.1093/nar/gkf481 · Cited by 796
Filonov, G. S., Moon, J. D., Svensen, N., & Jaffrey, S. R. (2014) · Journal of the American Chemical Society · doi:10.1021/ja508478x · Cited by 780
Structure of the HIV-1 Nucleocapsid Protein Bound to the SL3 Ψ-RNA Recognition Element
De Guzman, R. N., Wu, Z. R., Stalling, C. C., Pappalardo, L., Borer, P. N., & Summers, M. F. (1998) · Science · doi:10.1126/science.279.5349.384 · Cited by 659
Agris, P. F. (1996) · Progress in Nucleic Acid Research and Molecular Biology · doi:10.1016/s0079-6603(08)60143-9 · Cited by 274
Metadata
- Authors
- Heus, H. A., & Pardi, A.
- Venue
- Science
- Published
- 1991-07-12
- Volume
- 253
- Issue
- 5016
- Pages
- 191-194
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2066906496
- Cited by
- 620
- References
- 0
- FWCI
- 14.46
- Type
- journal article
- Language
- en
- Open access
- closed
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