Microanalysis of Individual Mitochondrial Granules with Diameters Less Than 1000 Angstroms
Abstract
A scanning electron microscope was converted to an electron microprobe with high spatial resolution by the addition of a transmitted electron detector and a solid-state x-ray detector. Spectra obtained from mitochondrial granules of chondrocytes in situ confirm the suspected presence of calcium and phosphorus. Contamination during analysis can lead to false indications of silicon in living tissue.
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Ca- and P-containing granules were identified within the mitochondria of osteoclasts, chondrocytes, osteoblasts, osteocytes, calcifying cartilage, and mineralizing bone if samples were prepared with anhydrous or cryo techniques.
“Ca- and P-containing granules were identified within the mitochondria of osteoclasts [116], chondrocytes [117, 118], osteoblasts [119], osteocytes [120–122], calcifying cartilage [123], and mineralizing bone [124–126] if samples were prepared with anhydrous or cryo techniques.”
From A Review of Phosphate Mineral Nucleation in Biology and Geobiology (2013) · cites this paper as [117]
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References 8 · Cited by 89
- Authors
- Sutfin, L. V., Holtrop, M. E., & Ogilvie, R. E.
- Affiliations
- Boston Children's Hospital (US)
- Massachusetts Institute of Technology (US)
- Venue
- Science
- Published
- 1971-11-26
- Volume
- 174
- Issue
- 4012
- Pages
- 947-949
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1974215555
- Cited by
- 89
- References
- 8
- Citations by year
- 2025: 1 · 2022: 1 · 2021: 4 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 1
- FWCI
- 3.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Electron and X-Ray Spectroscopy Techniques
- Physical Sciences › Physics and Astronomy › Radiation › X-ray Spectroscopy and Fluorescence Analysis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Structural Biology › Advanced Electron Microscopy Techniques and Applications
- Keywords
- mitochondrial granules, electron probe microanalysis, chondrocytes, calcium, phosphorus, silicon contamination, in situ elemental analysis, high spatial resolution, solid-state X-ray detectors
- MeSH terms
- Animals, Bone and Bones, Calcium, Methods, Microscopy, Electron, Scanning, Mitochondria, Phosphorus, Silicon, Spectrum Analysis, Mice
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