The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Cloning and Expression of the cDNA for Human γ-glutamyl Carboxylase
Abstract
The cDNA for human γ-glutamyl carboxylase, which accomplishes the post-translational modification required for the activity of all of the vitamin K-dependent proteins, was cloned. The enzyme is a 758-residue integral membrane protein and appears to have three transmembrane domains near its amino terminus. The hydrophilic COOH-terminal half of the carboxylase has 19.3 percent identity with soybean seed lipoxygenase. Expression of the cloned cDNA resulted in an increase in carboxylase activity in microsomes of transfected cells compared to mock-transfected cells.
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Cites
Improved tools for biological sequence comparison.
Pearson, W. R., & Lipman, D. J. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.8.2444 · Cited by 11,227
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Venter, J. C., Adams, M. D., Myers, E. W., Li, P. W., Mural, R. J., Sutton, G. G., Smith, H. O., Yandell, M., Evans, C. A., Holt, R. A., et al. (2001) · Science · doi:10.1126/science.1058040 · Cited by 13,909
REGULATION OF IMMUNE RESPONSES THROUGH INHIBITORY RECEPTORS
Long, E. O. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.875 · Cited by 939
Varnum, B. C., Young, C., Elliott, G., Garcia, A., Bartley, T. D., Fridell, Y.-W., Hunt, R. W., Trail, G., Clogston, C., Toso, R. J., et al. (1995) · Nature · doi:10.1038/373623a0 · Cited by 481
Vitamin K-Dependent Biosynthesis of γ-Carboxyglutamic Acid
Furie, B., Bouchard, B. A., & Furie, B. C. (1999) · Blood · doi:10.1182/blood.v93.6.1798.406k22_1798_1808 · Cited by 422
Rehemtulla, A., Roth, D. A., Wasley, L. C., Kuliopulos, A., Walsh, C. T., Furie, B., Furie, B. C., & Kaufman, R. J. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.10.4611 · Cited by 70
Metadata
- Authors
- Wu, S.-M., Cheung, W.-F., Frazier, D., & Stafford, D. W.
- Venue
- Science
- Published
- 1991-12-13
- Volume
- 254
- Issue
- 5038
- Pages
- 1634-1636
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2057755727
- Cited by
- 203
- References
- 1
- FWCI
- 7.43
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wu, S.-M., Cheung, W.-F., Frazier, D., & Stafford, D. W. (1991). Cloning and Expression of the cDNA for Human γ-glutamyl Carboxylase. Science. https://doi.org/10.1126/science.1749935
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
