The DOI matches its Crossref record.
1,25-Dihydroxycholecalciferol: Metabolite of Vitamin D 3 Active on Bone in Anephric Rats
Abstract
Nephrectomy prevents completely the bone calcium mobilization response to 25-hydroxycholecalciferol. In contrast it does not prevent this response to 1,25-dihydroxycholecalciferol. Because it is known that the kidney is the site of 1,25-dihydroxycholecalciferol formation, these results provide evidence that 1,25-dihydroxycholecalciferol or a further metabolite thereof and not 25-hydroxycholecalciferol is the metabolically active form of vitamin D 3 responsible for bone calcium mobilization.
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Citations
Cited by
Holick, M. F., Schnoes, H. K., DeLuca, H. F., Gray, R. W., Boyle, I. T., & Suda, T. (1972) · Biochemistry · doi:10.1021/bi00773a009 · Cited by 329
Self-citationHistory of the discovery of vitamin D and its active metabolites
DeLuca, H. F. (2014) · BoneKEy Reports · doi:10.1038/bonekey.2013.213 · Cited by 249
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Metadata
- Authors
- Holick, M. F., Garabedian, M., & DeLuca, H. F.
- Venue
- Science
- Published
- 1972-06-09
- Volume
- 176
- Issue
- 4039
- Pages
- 1146-1147
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2035869721
- Cited by
- 170
- References
- 0
- FWCI
- 26.21
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: 1,25-Dihydroxycholecalciferol: Metabolite of Vitamin D 3 Active on Bone in Anephric Rats. https://app.cochat.ai/papers/10.1126/science.176.4039.1146
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- Holick, M. F., Garabedian, M., & DeLuca, H. F. (1972). 1,25-Dihydroxycholecalciferol: Metabolite of Vitamin D 3 Active on Bone in Anephric Rats. Science. https://doi.org/10.1126/science.176.4039.1146
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
