Cell Culture on Artificial Capillaries: an Approach to Tissue Growth In Vitro
Abstract
Artificial capillaries perfused with culture medium provide a matrix in which cells can attain tissue-like densities in vitro. Products secreted into the medium can be measured as indicators of cell function or may be recovered for other purposes without disturbing the culture.
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More sophisticated bioreactor culture systems were first introduced in the 1970s to culture mammalian cells and typically involve the automated control of temperature, gas addition (O2, CO2), and/or acids and bases to maintain set targets for temperature, dissolved gases and pH.
“More sophisticated bioreactor culture systems were first introduced in the 1970s to culture mammalian cells (Knazek et al., 1972; Fouron, 1987) and typically involve the automated control of temperature, gas addition (O2, CO2), and/or acids and bases to maintain set targets for temperature, dissolved gases and pH.”
From Toward Best Practices for Controlling Mammalian Cell Culture Environments (2022) · cites this paper as Knazek et al., 1972
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References 18 · Cited by 424
- Authors
- Knazek, R. A., Gullino, P. M., Kohler, P. O., & Dedrick, R. L.
- Affiliations
- National Institutes of Health (US)
- Venue
- Science
- Published
- 1972-10-06
- Volume
- 178
- Issue
- 4056
- Pages
- 65-67
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1990185169
- Cited by
- 424
- References
- 18
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 3 · 2023: 9 · 2022: 10 · 2021: 9 · 2020: 2 · 2019: 3 · 2018: 5 · 2017: 1 · 2016: 3 · 2015: 5 · 2014: 7 · 2013: 6 · 2012: 6
- FWCI
- 6.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Keywords
- cell culture, extracellular matrix
- MeSH terms
- Acetates, Animals, Carbonates, Cell Line, Cells, Cultured, Cellulose, Choriocarcinoma, Culture Media, Diffusion, Female, Fibroblasts, Chorionic Gonadotropin, Humans, Methods, Microscopy, Phase-Contrast, Pregnancy, Silicones, Time Factors, Ultrafiltration, Culture Techniques, Mice
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