The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Survival of Mouse Embryos Frozen to -196° and -269°C
Abstract
Mouse embryos survived freezing to -196°C. Survival required slow cooling (0.3° to 2°C per minute) and slow warming (4° to 25°C per minute). Depending on the specific rates used, 50 to 70 percent of more than 2500 frozen and thawed early embryos developed into blastocysts in culture after storage at -196°C for up to 8 days. When approximately 1000 of the survivors, including some frozen to -269°C (4°K), were transferred into foster mothers, 65 percent of the recipients became pregnant. More than 40 percent of the embryos in these pregnant mice gave rise to normal, living full-term fetuses or newborn mice.
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Citations
Cites
Phase Diagram for the System Water–Dimethylsulphoxide
RASMUSSEN, D. H., & MACKENZIE, A. P. (1968) · Nature · doi:10.1038/2201315a0 · Cited by 383
Cited by
Elliott, G. D., Wang, S., & Fuller, B. J. (2017) · Cryobiology · doi:10.1016/j.cryobiol.2017.04.004 · Cited by 534
Han, Z., Rao, J. S., Gangwar, L., Namsrai, B.-E., Pasek-Allen, J. L., Etheridge, M. L., Wolf, S. M., Pruett, T. L., Bischof, J. C., & Finger, E. B. (2023) · Nature Communications · doi:10.1038/s41467-023-38824-8 · Cited by 173
Slow‐Freezing Injury in Mammalian Cells
Mazur, P. (1977) · Novartis Foundation Symposia · doi:10.1002/9780470720332.ch3 · Cited by 32
Self-citation
Metadata
- Authors
- Whittingham, D. G., Leibo, S. P., & Mazur, P.
- Venue
- Science
- Published
- 1972-10-27
- Volume
- 178
- Issue
- 4059
- Pages
- 411-414
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2942898131
- Cited by
- 738
- References
- 1
- FWCI
- 21.01
- Type
- journal article
- Language
- en
- Open access
- closed
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- Whittingham, D. G., Leibo, S. P., & Mazur, P. (1972). Survival of Mouse Embryos Frozen to -196° and -269°C. Science. https://doi.org/10.1126/science.178.4059.411
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
