The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Regulation of Polyphosphoinositide-specific Phospholipase C Activity by Purified G q
Abstract
The hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP 2 ) by phospholipase C yields the second messengers inositol 1,4,5-trisphosphate (InsP 3 ) and 1,2-diacylglycerol. This activity is regulated by a variety of hormones through G protein pathways. However, the specific G protein or proteins involved has not been identified. The α subunit of a newly discovered pertussis toxin-insensitive G protein (G q ) has recently been isolated and is now shown to stimulate the activity of polyphosphoinositide-specific phospholipase C (PI-PLC) from bovine brain. Both the maximal activity and the affinity of PI-PLC for calcium ion were affected. These results identify G q as a G protein that regulates PI-PLC.
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Citations
Cites
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Studies of Inositol Phospholipid-Specific Phospholipase C
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G Proteins in Signal Transduction
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Cited by
Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation
Balla, T. (2013) · Physiological Reviews · doi:10.1152/physrev.00028.2012 · Cited by 1,638
Regulation of Phosphoinositide-Specific Phospholipase C
Rhee, S. G. (2001) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.70.1.281 · Cited by 1,628
Hepler, J. R., & Gilman, A. G. (1992) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(92)90005-t · Cited by 894
Self-citationActivation of the β1 isozyme of phospholipase C by α subunits of the Gq class of G proteins
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Metadata
- Authors
- Smrcka, A. V., Hepler, J. R., Brown, K. O., & Sternweis, P. C.
- Venue
- Science
- Published
- 1991-02-15
- Volume
- 251
- Issue
- 4995
- Pages
- 804-807
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2090575139
- Cited by
- 894
- References
- 23
- FWCI
- 48.07
- Type
- journal article
- Language
- en
- Open access
- closed
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- Smrcka, A. V., Hepler, J. R., Brown, K. O., & Sternweis, P. C. (1991). Regulation of Polyphosphoinositide-specific Phospholipase C Activity by Purified G q. Science. https://doi.org/10.1126/science.1846707
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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