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Neurochemical Correlate of a Spatial Preference in Rats

Zimmerberg, Betty, Glick, Stanley D., Jerussi, Thomas P.·1974·Science

Abstract

Spatial (left or right) preferences were determined for rats given foot shock in a T-maze. The animals were killed, and left and right striata were assayed separately for dopamine and left and right teldiencephalic regions were assayed for norepinephrine. Dopamine content was significantly higher (by 12 percent) in the striata contralateral to rats' side preferences than in the ipsilateral striata; there was no such difference for teldiencephalic norepinephrine. The small asymmetry in striatal dopamine content is not due to any learning- or stress-related change induced by the testing procedure but is probably inherent in normal rats. Some spatial behavior appears to be the manifestation of a normal and specific difference in the activity of left and right nigrostriatal systems.

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Metadata

Authors
Zimmerberg, B., Glick, S. D., & Jerussi, T. P.
Venue
Science
Published
1974-08-16
Volume
185
Issue
4151
Pages
623-625
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2062695695
Cited by
266
References
0
FWCI
7.03
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Neurochemical Correlate of a Spatial Preference in Rats. https://app.cochat.ai/papers/10.1126/science.185.4151.623
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Zimmerberg, B., Glick, S. D., & Jerussi, T. P. (1974). Neurochemical Correlate of a Spatial Preference in Rats. Science. https://doi.org/10.1126/science.185.4151.623

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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.