The DOI matches its Crossref record.
Differentiation of 3T3-L1 Fibroblasts to Adipocytes Induced by Transfection of ras Oncogenes
Abstract
Mammalian 3T3-L1 cells differentiate into adipocytes after continuous exposure to pharmacological doses of insulin or physiological doses of insulin-like growth factor I (IGF-1). Expression of transfected ras oncogenes led to differentiation of these cells into adipocytes in the absence of externally added insulin or IGF-I. Cells transfected with normal ras genes or the tyrosine kinase trk oncogene did not differentiate. Transfection with a dominant inhibitory ras mutant resulted in inhibition of differentiation. Exposure of untransfected 3T3-L1 cells to insulin stimulated formation of the active Ras⋅GTP complex. These observations indicate that Ras proteins participate in signal transduction pathways initiated by insulin and IGF-I in these cells.
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Cited by
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., & Lowe, S. W. (1997) · Cell · doi:10.1016/s0092-8674(00)81902-9 · Cited by 5,218
Understanding Adipocyte Differentiation
GREGOIRE, F. M., SMAS, C. M., & SUL, H. S. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.3.783 · Cited by 2,376
Metadata
- Authors
- Benito, M., Porras, A., Nebreda, A. R., & Santos, E.
- Venue
- Science
- Published
- 1991-08-02
- Volume
- 253
- Issue
- 5019
- Pages
- 565-568
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1974997269
- Cited by
- 161
- References
- 0
- FWCI
- 3.68
- Type
- journal article
- Language
- en
- Open access
- closed
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- Benito, M., Porras, A., Nebreda, A. R., & Santos, E. (1991). Differentiation of 3T3-L1 Fibroblasts to Adipocytes Induced by Transfection of ras Oncogenes. Science. https://doi.org/10.1126/science.1857988
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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