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Cyclic Guanosine Monophosphate: Elevation in Degenerating Photoreceptor Cells of the C3H Mouse Retina
Abstract
As a result of an early deficiency in cyclic nucleotide phosphodiesterase activity, guanosine 3′,5′-monophosphate accumulates in retinal photoreceptor cells before they begin to degenerate. It is suggested that degeneration of the photoreceptor cells is related to an imbalance in their metabolism or function which is caused by the elevated levels of cyclic guanosine monophosphate.
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Citations
Cited by
Hartong, D. T., Berson, E. L., & Dryja, T. P. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69740-7 · Cited by 2,924
Bowes, C., Li, T., Danciger, M., Baxter, L. C., Applebury, M. L., & Farber, D. B. (1990) · Nature · doi:10.1038/347677a0 · Cited by 852
Self-citationCircadian photoreception in the retinally degenerate mouse (rd/rd)
Foster, R. G., Provencio, I., Hudson, D., Fiske, S., De Grip, W., & Menaker, M. (1991) · Journal of Comparative Physiology A · doi:10.1007/bf00198171 · Cited by 508
Photoreceptor cell rescue in retinal degeneration (rd) mice by in vivo gene therapy
Bennett, J., Tanabe, T., Sun, D., Zeng, Y., Kjeldbye, H., Gouras, P., & Maguire, A. M. (1996) · Nature Medicine · doi:10.1038/nm0696-649 · Cited by 316
Restoration of visual function in retinal degeneration mice by ectopic expression of melanopsin
Lin, B., Koizumi, A., Tanaka, N., Panda, S., & Masland, R. H. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806114105 · Cited by 302
Metadata
- Authors
- Farber, D. B., & Lolley, R. N.
- Venue
- Science
- Published
- 1974-11
- Volume
- 186
- Issue
- 4162
- Pages
- 449-451
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2028803712
- Cited by
- 410
- References
- 0
- FWCI
- 4.79
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Cyclic Guanosine Monophosphate: Elevation in Degenerating Photoreceptor Cells of the C3H Mouse Retina. https://app.cochat.ai/papers/10.1126/science.186.4162.449
- The paper
- Farber, D. B., & Lolley, R. N. (1974). Cyclic Guanosine Monophosphate: Elevation in Degenerating Photoreceptor Cells of the C3H Mouse Retina. Science. https://doi.org/10.1126/science.186.4162.449
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
